Online Football odds: Rams vs. 49ers

On Sunday late afternoon, the St. Louis Rams make the long trip to San Francisco to take on the 49ers. The game in Candlestick Park is scheduled to begin at 4:25 PM ET, and you can watch all of the action regionally on the FOX Network.

The Rams had Week 9 off, but were routed in Week 8 at home, losing to the New England Patriots, 45-7. This game was all New England, as the Rams gave up 29 first downs, 473 total yards, 321 passing yards, and 152 rushing yards. St. Louis was sacked twice and committed 12 penalties, which cost them over 125 yards. They also turned the ball over twice, throwing 2 interceptions. QB Sam Bradford threw 22-of-30, for 205 yards, and 1 touchdown. Bradford is at just 8 touchdowns and 7 interceptions on the season. The Rams have given up 75 points over their last 2 games. Check the NFL betting Odds for Rams vs. 49ers Game.

The 49ers also had Week 9 as a bye, but defeated the Arizona Cardinals on Monday Night in Week 8, 24-3. This game was all San Fran, as they held a 317-265 edge in total yards, and a 113-7 edge in rushing yards. They had scored all 24 of their points by the third quarter, before giving up one meaningless field goal to the Cardinals. QB Alex Smith threw 18-of-19, for 232 yards, and 3 touchdowns, setting the NFL record for the highest completion percentage in a game with at least 15 throws. Smith is at 15 touchdowns and 5 interceptions on the season so far.

The Rams are 5-3 ATS on the season, and 2-1 ATS as a road underdog. The 49ers are 5-3 ATS overall this year, and are 2-2 ATS when favored at home. Start your Bets on Football on Rams vs. 49ers Game.

These two teams have met 22 times since 2001, with the 49ers holding a 13-9 edge in the series. Their last meeting, in January 2012, resulted in a 34-27 Niners victory. In that one, San Francisco was a 10 ½ point favorite. In a December 2011 matchup, the Niners won 26-0, in a game in which they were favored by 13 ½ points. San Fran has covered in 3 of the last 5 meetings.

For this weekend's game, the 49ers are huge 11 ½ point home favorites, according to the SBG Sportsbook football odds page. The over/under is set at 38 ½ points.

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