During the past few years the best performing seed against the March Madness betting lines has been the #10 seed. They are hitting at about 70% against the March Madness odds. March Madness betting lines show that the #8 seeds have done pretty well hitting almost 70% against the spread the past few years. The worst seeds in March Madness betting lines are usually the #4 seeds in the early rounds. They have hit below 50% against the March Madness betting lines. Overall the seed that really struggles is the #7 seed. That makes sense since the #10 seed does the best in March Madness odds and the 10 versus 7 matchup occurs four times every year in the first round.
If you are looking at March Madness betting lines in terms of favorites and underdogs you should know that underdogs overall are profitable. This does not mean you can blindly take them all and expect to make a lot of cash versus the March Madness betting lines. You can make a little bit of money though. The small favorites really struggle against the March Madness betting lines. If a team is laying less than four points they are very poor against the March Madness odds. The mid-range big favorites are also very poor against the March Madness betting lines. Teams laying 8-14 points are below 40% against the March Madness odds. You should also keep in mind that the straight up winners of games usually cover the spread. This tells you two things. It says that if you are considering taking an underdog versus the betting line then you should also take them on the money line. If you are betting favorites then you want to lay the points and not play the money line. Straight up winners cover about three quarters of the time in the NCAA Tournament.
What do all of these numbers say in terms of March Madness betting lines? It tells you to first look at underdogs, especially in the early rounds of the NCAA Tournament. As the tournament continues you may be able to take some favorites versus the March Madness betting lines but caution is always advised when laying points.