UFC 322 Della Maddalena vs. Makhachev Main Card Betting Odds (11/15/2025)

MMA fans have rarely had it so good as they will on Saturday night. Specifically, UFC 322: Della Maddalena vs. Makhachev has a main card loaded with quality, fitting of its Madison Square Garden venue. Of course, the main event is the welterweight title bout between champion Jack Della Maddalena and Islam Makhachev. Additionally, Valentina Shevchenko will defend her women’s flyweight title belt against Zhang Weili.

Three other matchups of ranked combatants complete one of the best UFC Betting main cards in recent memory. #2-ranked Sean Brady will face #8-ranked Michael Morales in a welterweight matchup. Also from the welterweight division is a fight between #4-ranked Leon Edwards and #9 Carlos Prates. Finally, #9-ranked Beneil Dariush takes on #13-ranked Benoit Saint Denis.

With such a loaded card and two championship bouts, betting interest and activity will be among the highest in several years.

UFC 322 Della Maddalena vs. Makhachev Main Card

Welterweight Championship Bout

Jack Della Maddalena has a career sports betting record of 18-2. In comparison, Islam Makhachev has a career mark of 27-1.

Jack Della Maddalena indeed lost the first two fights of his career. Since then, he has never lost a fight. In his most recent bout, Della Maddalena won the most important fight of his career on May 10, 2025. On that night, Della Maddalena won a unanimous decision against Belal Muhammad at UFC 315 in Montreal. Now comes his first defense of that title belt against Makhachev.

Meanwhile, Islam Makhachev is one of the UFC’s elite fighters. Concurrently, he is the #1-ranked lightweight combatant and is #2 in the UFC men’s pound-for-pound rankings. Makhachev is the former UFC lightweight champion.

Last time out, Makhachev defended his UFC lightweight title in a 1st-round submission against Renato Moicano on January 18, 2025, in Inglewood, CA. Makhachev originally won the championship on October 22, 2022, in a 2nd-round submission win over Charles Oliveira. He has successfully defended his title belt four times. Makhachev defeated two challenges by Alexander Volkanovski. Additionally, he won a title defense bout against Dustin Poirier.

Women’s Flyweight Title Bout

Overall, Valentina Shevchenko has a career record of 25-4-1. Zhang Weili stands at 26-3 for her career.

Valentina Shevchenko is a 2-time current women’s flyweight champion. Additionally, she is the top-ranked women’s pound-for-pound combatant. Shevchenko is coming off a unanimous decision win over Manon Fiorot on May 10, 2025, in Montreal. With the win, she retained her UFC women’s flyweight title.

Previously, on September 14, 2024, Shevchenko won a unanimous decision against Alexa Grasso in Las Vegas to win the UFC women’s flyweight title. The bout was a rematch from a draw between the two combatants on September 16, 2023, in Las Vegas.

Zhang Weili is the former 2-time UFC women’s strawweight champion. She made history by being the first Chinese fighter to win a UFC title belt. Late on, Weili is riding a 5-bout winning streak. She is coming off a successful defense of her UFC strawweight title by unanimous decision against Tatiana Suarez. That bout took place on February 9, 2025, in Sydney.

Welterweight Bout

Sean Brady has a career record of 18-1. In comparison, Michael Morales has a career UFC Betting odds record of 18-0.

Welterweight Bout

To summarize, Leon Edwards has a career record of 22-5 and 1 NC. Carlos Prates stands at 22-7 for his MMA career.

Lightweight Bout

Beneil Dariush has a career MMA record of 23-6-1. Correlate that Benoit Saint Denis brings a record of 15-3 to the octagon.

UFC 322 Free Picks

In the main event, Jack Della Maddalena is a live dog as the defending champion against Islam Makhachev, who seems overpriced. Meanwhile, Zhang Weili is in top form as the underdog against Valentina Shevchenko.

UFC 322 Best Bets: Jack Della Maddalena & Zhang Weili.