Matt Breida scampered through the Cleveland defense for 114 yards as San Francisco handed the Browns a 31-3 defeat on Monday at Levi's Stadium.
Bettors who backed the 49ers were also rewarded, as they covered the closing number as a favorite of -5.0 at sportsbooks. Over-Under bettors saw the total score go UNDER the closing total of 47.5.
Matt Breida rushed for 114 yards, while Tevin Coleman added 97 yards in the win. George Kittle and Marquise Goodwin added 70 and 41 receiving yards respectively.
Nick Chubb rushed for 87 yards for Cleveland, while Odell Beckham Jr. added 15 yards. Odell Beckham Jr. threw for 20 yards for the Browns, while receivers Jarvis Landry and Odell Beckham Jr. had 75 and 27 yards respectively.
Cleveland lost the offensive yardage battle to San Francisco 446-180 yards in Monday's game. San Francisco had more first downs as that total ended up 22-9.
Cleveland lost the time of possession battle 37:43-22:17, leaving their defense on the field more than they wanted.
San Francisco heads into a Week 6 battle against the Rams. Cleveland, meanwhile, will have their next action against Seattle.