Oregon Ducks at Penn State Nittany Lions College Football Odds (09/27/2025)

Last year, the Penn State Nittany Lions met the Oregon Ducks in the Big Ten Championship Game. Oregon was a new member of the Big Ten and was taking less money than the established schools to join. However, the Big Ten should have been giving Oregon a raise after winning the league in 2024. Now, Penn State gets a shot at College Football odds revenge at home on Saturday. The Ducks and Nittany Lions will play in the famed annual White Out at Beaver Stadium. So far, Penn State and Oregon are the biggest matchups of 2025.

Oregon Ducks at Penn State Nittany Lions

Odds at SBG Sportsbook

Team	Spread	Total	ML
Oregon	+3½ ( -103 )	52½ ( -108 )	+150
Penn State	-3½ ( -117 )	52½ ( -112 )	-171

Oregon Ducks Team Overview

Last game, the Oregon Ducks won 41-7 against the Oregon State Beavers as 34-point home favorites. The game went under the Offshore betting total of 58. As a result, Oregon is 4-0 straight up, 2-1-1 against the spread, and 2-2 over the total.

Overall, Oregon has national metrics of 12th for total offense, 7th for scoring offense, and 12th for fewest turnovers committed. By contrast, Oregon ranks 12th for total defense, 9 for points allowed, and 36th for takeaways.

Sixth-ranked Oregon tuned up for its massive Big Ten showdown at Penn State next weekend. In turn, the Ducks scored a romp over in-state rival Oregon State on Saturday afternoon in Eugene, Ore.

Overall, the Ducks racked up 585 yards of total offense. Quarterback Dante Moore completed 21 of 31 passes for 305 yards with four touchdowns. Moore, along with six running backs helped the Ducks run for 280 yards.

Jayden Limar, elevated to the starter with Noah Whittington missing a second straight week with an unspecified injury, ran the ball 12 times for 70 yards to lead the ground game. Moore added 53 rushing yards. Finally, Jordon Davison’s 3-yard touchdown run with 21 seconds left in the first half gave Oregon a 21-7 lead going into halftime.

Penn State Nittany Lions Team Overview

Last week, the Penn State Nittany Lions won 52-6 against the FCS Villanova Wildcats as 47.5-point home favorites. The game went over the total of 56.6. Accordingly, Penn State is 3-0 straight up, 0-3 against the spread, and 2-1 over the total. 

In sum, Penn State has national metrics of 47th for total offense, 13th for scoring offense, and 8th for fewest turnovers committed. In comparison, Penn State ranks 9th for total defense, 3rd for points allowed, and 26th for takeaways. 

Nicholas Singleton ran for two touchdowns and Drew Allar threw for a touchdown as No. 2 Penn State cruised over visiting Villanova. To summarize, Allar finished 16-of-29 for 209 yards with a touchdown and an interception. Kaytron Allen ran for a team-high 86 yards. And then Singleton ran 20 times for 84 yards for the Nittany Lions. Additionally, Trebor Pena chipped in 60 receiving yards and a touchdown on four catches.

At the onset, Penn State opened the game with a 12-play, 78-yard touchdown drive. The Nittany Lions converted a pair of third downs on the march before Singleton punctuated the drive with a 4-yard TD run.

Oregon at Penn State Betting Trends

Oregon has been a strong value on the road. To show, the Ducks covered ten of their most recent 15 road games. Seven of the last 11 Oregon road games went under the total. 

Specifically at home, Penn State has not been a reliable wagering value. The Nittany Lions got the cash in only four of their previous 13 home games. Penn State went under the total in eight of its last 12 games. 

Last year, in the only previous meeting between these teams, the Ducks beat the Nittany Lions 45-37 as 3-point favorites in the Big Ten championship game. The matchup went over the total of 52.

Oregon at Penn State SBG Free Picks

On this occasion, Oregon will offer more value as the power away team with the College Football odds. The White Out is going to draw too much square money to Penn State.  

Oregon at Penn State SBG Best Bet:

Oregon Ducks