Since losing the NFC championship game in 2015, the Arizona Cardinals have had one winning season and playoff berth (2021). Head coach Jonathan Gannon is in his third season as head coach. Correlate that the Cardinals continue to improve under his leadership. Following two wins to begin the season, the Cardinals played at San Francisco on Sunday. Arizona suffered a painful loss to halt its NFL Odds momentum. Second-year head coach Mike Macdonald and his Seattle Seahawks are off to a promising start as well. Now Seattle heads to the desert to take on the Cardinals Thursday night.
Seattle Seahawks at Arizona Cardinals NFL Betting Information
| Date and Time: | Thursday, September 25, 2025, 8:15 p.m. ET |
|---|---|
| Location: | State Farm Stadium, Glendale, AZ |
| TV Coverage: | Prime Video |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Seahawks | PK ( -111 ) | 43½ ( -105 ) | – |  |
| Cardinals | PK ( -109 ) | 43½ ( -115 ) | – | |
| ||||
Seattle Seahawks Team Overview
Last week, the Seattle Seahawks beat the New Orleans Saints 44-13 as 7.5-point home favorites. The game went over the sportsbook total of 42. As a result, Seattle is 2-1 straight up, 2-1 against the spread, and 2-1 over the total.
Seattle has NFL metrics of 18th for total offense, 5th for scoring offense, and 24th for fewest turnovers committed. In comparison, Seattle ranks 14th in total defense, 2nd in points allowed, and 2nd in takeaways.
Rookie Tory Horton scored two touchdowns, one on a franchise-record punt return, as the Seattle Seahawks trounced the visiting New Orleans Saints.
Kenneth Walker III rushed for a pair of short TDs for the Seahawks. Also, Sam Darnold completed 14 of 18 passes for 218 yards and two touchdowns.
Horton returned Kai Kroeger’s punt 95 yards for a score, besting the mark of 94 set by Charlie Rogers in 1999. And it was matched by Nate Burleson in 2007. Also, it was the Seahawks’ first TD on a punt return since Tyler Lockett accomplished the feat in his NFL debut in 2015.
Arizona Cardinals Team Overview
Last game, the Arizona Cardinals lost 16-15 to the San Francisco 49ers. The game went under the total of 44.5. Now, Arizona is 2-1 straight up, 2-1 against the spread, and 1-2 under the total.
Arizona has NFL metrics of 25th for total offense, 29th for passing, and 21st for scoring. In turn, the Cardinals rank 22nd for total defense, 29th against the pass, 3rd against the rush, and 5th for points allowed.
Eddy Pineiro drilled a 35-yard field goal as time expired to lift the San Francisco 49ers to a win over the Arizona Cardinals on Sunday afternoon in Santa Clara, Calif. In sum, Kyler Murray completed 22 of 35 passes for 159 yards and one touchdown for Arizona. Trey McBride had a team-high five catches for 43 yards and a score. The score was even at 13-all with 8:37 to go in the fourth quarter after McBride hauled in a 1-yard scoring pass from Murray.
Seahawks at Cardinals Betting Trends
Late on Seattle has been a good value on the road. The Seahawks got the cash in five of their most recent seven away games. The Seahawks went over the total in four of their last five road matchups.
In like manner, the Cardinals have been a good value at home. Arizona covered the spread in five of its latest seven home games. The Cardinals went over the total in five of their last eight home games.
In this series between the Seahawks and Cardinals, Seattle got the cash in six of the last seven meetings. Four of the most recent six meetings between the Cardinals and Seahawks went under the total.
Specifically at Arizona, Seattle got the cash in three of its most recent four visits. Four of the last five games between the Seahawks and Cardinals at Arizona went over the total.
Seahawks at Cardinals SBG Free Picks
As was previously noted, Seattle brings good NFL Betting value on the road and against the Cardinals. Also, this is an over/under total for the entire series.
Seahawks at Cardinals SBG Best Bets: Seattle Seahawks and Over the Total.