From the 1950s through the 1980s, the Los Angeles Rams and San Francisco 49ers had one of the great NFL odds rivalries. But since the Rams moved to St. Louis only to return later, the old flame flickers on and off. However, the Rams and Niners have a shot at turning up the heat with an important Thursday night matchup. The visiting 49ers were written off when Brock Purdy was sidelined with an injury. Instead, they kept winning. Following wins in their first two games, LA suffered a soul-crushing loss at Philadelphia, casting doubts on their viability.
San Francisco 49ers vs. Los Angeles Rams NFL Betting Information
| Date and Time: | Thursday, October 2, 2025, 8:15 p.m. ET |
|---|---|
| Location: | SoFi Stadium, Inglewood, CA |
| TV Coverage: | Prime Video |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| 49ers | +3½ ( EV ) | 46½ ( -115 ) | +180 |  |
| Rams | -3½ ( -120 ) | 46½ ( -105 ) | -210 | |
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San Francisco 49ers Team Overview
Last game, the San Francisco 49ers lost 26-21 to the Jacksonville Jaguars as 3.5-point home favorites. The game went over the online betting total of 46. As a result, the 49ers are 3-1 straight up, 2-2 against the spread, and 2-2 over the total.
Overall, the 49ers have NFL metrics of 5th for total offense, 2nd for passing, 29th for rushing, 22nd for scoring, and 29th for fewest turnovers committed. In comparison, the Niners rank 5th for total defense, 6th for points allowed, but 30th for takeaways.
Travis Etienne ran for 124 yards and a touchdown, while Trevor Lawrence added a passing touchdown. Hence, the Jacksonville Jaguars handed the San Francisco 49ers their first loss. Jacksonville secured the win with a big defensive play on a day they forced four turnovers. Arik Armstead sacked Brock Purdy, causing a fumble that teammate Foyesade Oluokun recovered at the San Francisco 47 with 2:47 left.
Overall, Lawrence completed 21 of 31 passes for 174 yards. He hit Hunter Long for an 8-yard gain on 3rd-and-5 at the two-minute warning to help the Jaguars run out the clock.
Los Angeles Rams Team Overview
Last week, the Los Angeles Rams won 27-20 against the Indianapolis Colts as 3.5-point home favorites. The game went under the total of 50. Now, Los Angeles is 3-1 straight up, 3-1 against the spread, and 2-2 over the total.
The Rams have NFL metrics of 4th for total offense, 3rd for passing, 13th for rushing, and 13th for scoring. In comparison, LA ranks 9th for total defense and 9th for points allowed.
Matthew Stafford connected with Tutu Atwell on an 88-yard touchdown pass with under two minutes remaining. Hence, the Los Angeles Rams rallied for a victory over the visiting Indianapolis Colts. Overall, Stafford was 29-of-41 passing for 375 yards and three touchdowns. At the same time, Puka Nacua had 13 receptions for a career-high 170 yards.
49ers at Rams Betting Trends
The 49ers have drowned gamblers with red ink in recent road games. San Francisco failed to get the money in eight of its most recent 11 road games. The 49ers went over the total in ten of their last 15 road tilts.
The Rams have been a solid betting value at home. Los Angeles has covered 12 of their last 20 home games. Including four of their most recent five at SoFi Stadium. The Rams went under the total in 11 of their last 18 home games.
In the series between San Francisco and Los Angeles, the 49ers covered the spread in 13 of the last 20 meetings. However, the Rams covered the four most recent games. Four of the last five games between the 49ers and Rams went over the total.
Specifically in Los Angeles, the 49ers got the money in nine of their last 13 meetings with the Rams. But the Rams covered the last two games in this series at SoFi Stadium. The Rams and 49ers went over the total in 11 of their last 16 games at LA.
49ers at Rams SBG Free Picks
As mentioned earlier, the Rams show good NFL Betting value at home. By contrast, the 49ers are unreliable values on the road. Late on, the Rams have owned the advantage in this series.
49ers at Rams SBG Best Bets: Los Angeles Rams.