NFL Week 4 opens with an Amazon Prime Thursday night matchup between the visiting Seattle Seahawks and the Arizona Cardinals. Seattle is coming off a surprisingly good 10-7 season under Mike Macdonald, a rookie head coach. Now, Sam Darnold arrives from Minnesota, where he was the quarterback of a 14-3 team. Darnold figures to be an upgrade for the Seahawks. Meanwhile, Arizona was 8-9 last year. Following a 4-13 record in the 2023 campaign. Kyler Murray remains under center for the Cardinals, who showed marked NFL odds improvement under Jonathan Gannon. Also, Gannon was his rookie HC season.
2025-26 NFL Super Bowl Championship Future Odds
| Team | Odds |
|---|---|
| Philadelphia Eagles | +650 |
| Buffalo Bills | +700 |
| Baltimore Ravens | +700 |
| Kansas City Chiefs | +750 |
| Detroit Lions | +1000 |
| Washington Commanders | +1800 |
| San Francisco 49ers | +2000 |
| Green Bay Packers | +2000 |
| Cincinnati Bengals | +2000 |
| Los Angeles Rams | +2200 |
| Denver Broncos | +2500 |
| Tampa Bay Buccaneers | +2800 |
| LA Chargers | +2800 |
| Minnesota Vikings | +3000 |
| Chicago Bears | +3000 |
| Pittsburgh Steelers | +3500 |
| Houston Texans | +4000 |
| Seattle Seahawks | +4000 |
| New England Patriots | +6000 |
| Dallas Cowboys | +6000 |
| Arizona Cardinals | +6000 |
| Miami Dolphins | +8000 |
| Jacksonville Jaguars | +8000 |
| Atlanta Falcons | +8000 |
| Las Vegas Raiders | +12000 |
| Indianapolis Colts | +12000 |
| Carolina Panthers | +14000 |
| Tennessee Titans | +18000 |
| New York Giants | +18000 |
| New York Jets | +20000 |
| Cleveland Browns | +25000 |
| New Orleans Saints | +30000 |
2024-25 NFL Week 4 Schedule
Thursday, Sept. 25
- Seattle Seahawks at Arizona Cardinals, 8:15 p.m. ET (Prime Video)
Sunday, Sept. 28
- Minnesota Vikings vs Pittsburgh Steelers (Dublin, Ireland), 9:30 a.m. ET (NFL Network)
- Washington Commanders at Atlanta Falcons, 1 p.m. ET (CBS)
- New Orleans Saints at Buffalo Bills, 1 p.m. ET (CBS)
- Cleveland Browns at Detroit Lions, 1 p.m. ET (FOX)
- Tennessee Titans at Houston Texans, 1 p.m. ET (CBS)
- Carolina Panthers at New England Patriots, 1 p.m. ET (FOX)
- Los Angeles Chargers at New York Giants, 1 p.m. ET (CBS)
- Philadelphia Eagles at Tampa Bay Buccaneers, 1 p.m. ET (FOX)
- Indianapolis Colts at Los Angeles Rams, 4:05 p.m. ET (FOX)
- Jacksonville Jaguars at San Francisco 49ers, 4:05 p.m. ET (FOX)
- Baltimore Ravens at Kansas City Chiefs, 4:25 p.m. ET (CBS)
- Chicago Bears at Las Vegas Raiders, 4:25 p.m. ET (CBS)
- Green Bay Packers at Dallas Cowboys, 8:20 p.m. ET (NBC)
Monday, Sept. 29
- New York Jets at Miami Dolphins, 7:15 p.m. ET (ESPN)
- Cincinnati Bengals at Denver Broncos, 8:15 p.m. ET (ABC)
Week 4 Overview
The NFC West appears to be one of the most competitive divisions in online betting. Hence, that makes Thursday night’s game particularly important.
Specifically in the late Sunday window, fans and gamblers are treated to a powerhouse matchup from the AFC. To illustrate, the Kansas City Chiefs will host the Baltimore Ravens. Baltimore and Kansas City have developed a notable NFL betting odds rivalry over the years as regular top contenders. The quarterback matchup of Lamar Jackson and Patrick Mahomes speaks for itself. So too does the coaching showdown of Baltimore’s John Harbaugh and Kansas City’s Andy Reid.
Lamar Jackson has to be tired of hearing that he is a multi-MVP award winner who cannot reach the Super Bowl. Thus, his matchup with Mahomes accentuates that reputation. The Chiefs and Ravens could serve as a potential playoff preview, and it will come as no surprise if they clash in the AFC Championship game.
Also, the late Sunday afternoon window features an interesting matchup of historic brands when the Las Vegas Raiders host the Chicago Bears. Ben Johnson is the rookie head coach of the Bears. Specifically, he was hired to help Caleb Williams reach his quarterback potential as the first player taken in the 2024 NFL Draft. Johnson made his reputation as the offensive coordinator of the Detroit Lions, where he helped resurrect the career of Jared Goff.
Speaking of name-brand matchups, the Dallas Cowboys will host the Green Bay Packers on NBC’s Sunday Night Football. This matchup means TV ratings and a massive betting handle. Namely, Brian Schottenheimer was not a popular pick to replace Mike McCarthy as head coach of the Cowboys. But he can quiet his critics with a playoff season in 2025.
Correlate that Matt LaFleur replaced McCarthy as head coach in Green Bay and has done a credible job. Green Bay upset McCarthy’s best Dallas team in the 2023 NFC playoffs in an unforgettable performance.