Week 5 of the 2025 NFL season opens with a Thursday night Prime Video matchup of the San Francisco 49ers at the Los Angeles Rams. Decades ago, this was one of the better NFL odds rivalries. And there have been some important matchups between these teams in recent years. The most important game in the current era was the 2021 NFC championship game, which the Rams came from behind to win 20-17 en route to their Super Bowl championship. The 49ers are coming off a lost season due to a massive injury list headed by Christian McCaffrey.
2025-26 NFL Super Bowl Championship Future Odds
| Team | Odds |
|---|---|
| Philadelphia Eagles | +650 |
| Buffalo Bills | +700 |
| Baltimore Ravens | +700 |
| Kansas City Chiefs | +750 |
| Detroit Lions | +1000 |
| Washington Commanders | +1800 |
| San Francisco 49ers | +2000 |
| Green Bay Packers | +2000 |
| Cincinnati Bengals | +2000 |
| Los Angeles Rams | +2200 |
| Denver Broncos | +2500 |
| Tampa Bay Buccaneers | +2800 |
| LA Chargers | +2800 |
| Minnesota Vikings | +3000 |
| Chicago Bears | +3000 |
| Pittsburgh Steelers | +3500 |
| Houston Texans | +4000 |
| Seattle Seahawks | +4000 |
| New England Patriots | +6000 |
| Dallas Cowboys | +6000 |
| Arizona Cardinals | +6000 |
| Miami Dolphins | +8000 |
| Jacksonville Jaguars | +8000 |
| Atlanta Falcons | +8000 |
| Las Vegas Raiders | +12000 |
| Indianapolis Colts | +12000 |
| Carolina Panthers | +14000 |
| Tennessee Titans | +18000 |
| New York Giants | +18000 |
| New York Jets | +20000 |
| Cleveland Browns | +25000 |
| New Orleans Saints | +30000 |
2024-25 NFL Week 5 Schedule
Thursday, Oct. 2
- San Francisco 49ers at Los Angeles Rams, 8:15 p.m. ET (Prime Video)
Sunday, Oct. 5
- Minnesota Vikings vs Cleveland Browns (Tottenham, London), 9:30 a.m. ET (NFL Network)
- Houston Texans at Baltimore Ravens, 1 p.m. ET (CBS)
- Miami Dolphins at Carolina Panthers, 1 p.m. ET (FOX)
- Las Vegas Raiders at Indianapolis Colts, 1 p.m. ET (FOX)
- New York Giants at New Orleans Saints, 1 p.m. ET (CBS)
- Dallas Cowboys at New York Jets, 1 p.m. ET (FOX)
- Denver Broncos at Philadelphia Eagles, 1 p.m. ET (CBS)
- Tennessee Titans at Arizona Cardinals, 4:05 p.m. ET (CBS)
- Tampa Bay Buccaneers at Seattle Seahawks, 4:05 p.m. ET (CBS)
- Detroit Lions at Cincinnati Bengals, 4:25 p.m. ET (FOX)
- Washington Commanders at Los Angeles Chargers, 4:25 p.m. ET (FOX)
- New England Patriots at Buffalo Bills, 8:20 p.m. ET (NBC)
Monday, Oct. 6
- Kansas City Chiefs at Jacksonville Jaguars, 8:15 p.m. ET (ABC/ESPN)
Specifically, Tottenham Hotspur Stadium is best known as the home of the famed English Premier League soccer club. However, on Sunday morning, October 5, it will host a National Football League game between the Minnesota Vikings and the Cleveland Browns. And it promises to be a potential circus.
Shedeur Sanders was drafted much later than most experts expected. But he finally landed with the Cleveland Browns, who have a seriously questionable quarterback room. Sanders is receiving all the media’s attention. In turn, that will only increase as training camp progresses.
Meanwhile, in the late afternoon sportsbook window, the Detroit Lions will visit the Cincinnati Bengals. It is a key interconference matchup that could also be a Super Bowl preview. Detroit believes it would have made the Super Bowl last year if not for an injury to DE Aidan Hutchinson. Also, Cincinnati believes they were Super Bowl material if not for QB Joe Burrow missing most of the campaign.
NBC Sunday Night Football features an AFC East matchup between the New England Patriots and the Buffalo Bills. New England’s one-year Jerod Mayo experiment ended after a brutal 4-13 record. But it must be admitted that Bill Belichick left an empty cupboard and a demoralized franchise.
Now, Mike Vrabel has come home to New England, where he was a former player. Vrabel is best known for his success as head coach of the Tennessee Titans. In sum, he went 54-45 in six seasons with three playoff appearances. Vrabel will bring a sense of order, physicality, and fundamental football that is essential for success.
Namely, Drake Maye has plenty of on-the-job training after a solid rookie campaign on a terrible New England team that was poorly led. There is NFL betting odds faith that Vrabel can build a coherent offense and team around Maye.
Regardless of Vrabel and New England’s potential, a Sunday night game at the Buffalo Bills will be a tall order.