NFL odds Week 1 kicks off with a number of interesting games, one of the most interesting, perhaps, being Kansas City Chiefs vs. New England Patriots. NFL Week 1 show that the Patriots are the favorites for this NFL Week 1 season opening match, at -16½.It seems as if many people betting on the Patriots during NFL Week 1 are expecting similar performance to last season, where they went nearly undefeated (until the Giants smeared their hopes to go 19-0 at the Super Bowl). However, NFL Week 1 enthusiasts can tell their performance during the preseason doesn’t show signs of another perfect season.