Since their 1960 inception, the Chargers and Broncos have played in the same division as charter members of the American Football League. Thus, Denver and Los Angeles have one of the best rivalries in pro football. Now, the Broncos and Chargers see an opening in the AFC West. The Kansas City Chiefs are nearing a decade as a dynasty. Consider that betting on NFL history shows around a decade is all that you get. The Bo Nix and Sean Payton combination has rejuvenated Denver. While Jim Harbaugh and Justin Herbert have been a bolt of energy for LA.
Denver Broncos vs. Los Angeles Chargers NFL Betting Information
| Date and Time: | Sunday, September 21, 2025, 4:05 p.m. ET |
|---|---|
| Location: | SoFi Stadium, Inglewood, CA |
| TV Coverage: | CBS |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Broncos | +3 ( -120 ) | 46 ( -110 ) | +130 |  |
| Chargers | -3 ( EV ) | 46 ( -110 ) | -150 | |
| ||||
Denver Broncos Team Overview
Last week, the Denver Broncos lost 29-28 to the Indianapolis Colts as 1-point road favorites. The game went over the online betting total of 43. As a result, the Broncos are 1-1 straight up, 0-2 against the spread, and 1-1 over the total. Overall, the Broncos rank 23rd for total offense, 12th for scoring offense, and 32nd for fewest turnovers committed. Denver ranks 11th for total offense, 18th for fewest points allowed, and 30th for takeaways.
Spencer Shrader kicked a 45-yard field goal with no time left, his fifth of the game, and the host Indianapolis Colts rallied to beat the Denver Broncos. Previously, Denver led 28-26 late in the fourth quarter when Will Lutz missed a 42-yard field goal with 3:19 remaining.
Bo Nix threw touchdown passes to Troy Franklin, Marvin Mims Jr., and Adam Trautman. In sum, he finished 22-for-30 passing for 206 yards and an interception. Also, JK Dobbins ran for 76 yards and a score for Denver.
LA Chargers Team Overview
Last week, the LA Chargers beat the Las Vegas Raiders 20-9 as -3.5 road favorites. The game went under the total of 46.5. The Chargers are 2-0 straight up, 2-0 against the spread, and 1-1 over the total. Overall, Los Angeles ranks 11th for total offense, 13th for scoring offense, and 15th for fewest turnovers committed. By contrast, the Chargers rank 7th for total defense, 4th for fewest points allowed, and 6th for takeaways.
Justin Herbert passed for 242 yards and two touchdowns. Also, Keenan Allen and Quentin Johnston caught scoring passes as the Chargers defeated the Raiders for the third straight time. Daiyan Henley, Tony Jefferson, and Donte Jackson each had an interception for Los Angeles.
Overall, Herbert completed 19 of 27 passes and had a team-best 31 rushing yards on nine carries for Los Angeles. LA outgained the Raiders 317-218 in total yards.
Broncos at Chargers Betting Trends
On the road, the Denver Broncos got the money in six of their most recent 10 games in that role. Denver went over the total in five of their last seven away games.
Meanwhile, the LA Chargers are 6-3 against the spread in home games. Los Angeles went over the total in seven of their most recent 11 home games.
In the series between Denver and LA, the Broncos got the money in seven of the most recent 12 meetings. Five of the last nine games between Denver and LA went under the total.
Specifically at LA, the Broncos paid out in four of their most recent seven visit to LA. The Chargers and Broncos went under the total in 12 of their last 15 meetings at LA.
Broncos at Chargers SBG Free Picks
To conclude, in an even matchup, Denver will offer more Betting on NFL value with the away team price. As mentioned earlier, Denver has good value against the Chargers, and the series trends under.
Broncos at Chargers SBG Best Bet: Denver Broncos and Under the Total.