On Thursday, Prime Video will kick off NFL Week 3 with an AFC rivalry matchup that dates back to 1966, when the American Football League was established. Additionally, this game will provide a stark contrast in team culture. The Miami Dolphins have a poor NFL Odds reputation for being soft. By contrast, the Buffalo Bills are known as resilient and tough as nails. Buffalo will host Miami on Thursday night in an important game that could determine the future path for the 2025 season. Following its Week 1 thriller over the Baltimore Ravens, Buffalo routed the New York Jets.
Miami Dolphins vs. Buffalo Bills NFL Betting Information
| Date and Time: | Thursday, September 18, 2025, 8:15 p.m. ET |
|---|---|
| Location: | Highmark Stadium, Orchard Park, NY |
| TV Coverage: | Prime Video |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Dolphins | +11½ ( -110 ) | 49½ ( -115 ) | +564 |  |
| Bills | -11½ ( -110 | )49½ ( -105 ) | -805 | |
| ||||
Miami Dolphins Team Overview
Last week, the Miami Dolphins lost 33-27 to the New England Patriots as 2.5-point home favorites. The game went over the sportsbook total of 42.5. Miami is 0-2 straight up, 0-2 against the spread, and 1-1 over the total. Overall, Miami ranks 5th in total offense but 32nd in scoring and 29th in fewest turnovers committed. The Dolphins rank 31st in total defense, 30th in fewest points allowed, and 27th in takeaways.
Antonio Gibson’s 90-yard kickoff return for a touchdown helped the New England Patriots post a win over the Miami. Specifically, Gibson’s first career touchdown return was the difference in the game. The Dolphins drove into New England territory in the final 90 seconds. But the drive ended on Milton Williams’ second sack of the game on fourth-and-12 at the 28-yard line.
Miami quarterback Tua Tagovailoa completed 26 of 32 passes for 315 yards and two touchdowns, with one interception. Also, Tyreek Hill energized the offense with 109 yards on six catches. De’Von Achane led the Dolphins with 30 rushing yards and also contributed 92 receiving yards and a touchdown.
Buffalo Bills Team Overview
Last game, the Buffalo Bills won 30-10 against the New York Jets as 6-point road favorites. The game went under the total of 47.5. Buffalo is 2-0 straight up, 2-0 against the spread, 1-1 over the total. Buffalo ranks 8th for total offense and 2nd for scoring offense. In comparison, the Bills rank 6th in total defense, 22nd in points allowed, and 29th in takeaways.
James Cook rushed for 132 yards with two touchdowns, Matt Prater booted three field goals, and the Buffalo Bills won over the New York Jets. Overall, the Bills dominated, holding a 403-154 edge in total yardage and a 25-11 margin in first downs over the Jets.
Buffalo’s bruising ground game, primarily between the tackles, managed 224 yards on 43 attempts. Also, Josh Allen completed 14 of 25 passes for 148 yards and rushed for 59 yards. Mitch Trubisky completed a 32-yard pass in a brief relief stint when Allen was given a bloody nose in the second quarter.
Dolphins at Bills Betting Stats
Miami has been a weak betting value on the road. To show, the Dolphins have covered the spread in only six of their last 17 games in that role. Miami went under the total in 12 of its most recent 18 road games.
In comparison, Buffalo got the money in eight of its most recent ten home games. The Bills went over the total in 11 of their last 14 home games.
In this series, Buffalo is 5-4-1 against the spread vs. Miami with only one straight-up loss in that span. Four of the most recent six games between the Bills and Dolphins went over the total. Specifically at Buffalo, the Dolphins are 3-1-1 against the spread in their most recent five visits. Additionally, the Bills and Dolphins exceeded the total in nine of their last 10 games at Buffalo.
Dolphins at Bills SBG Free Picks
In this situation, Miami makes for a contrarian NFL Betting pick. Too much public money is on Buffalo.
Dolphins at Bills SBG Best Bets: Miami Dolphins.