Previously this season, the San Francisco 49ers won a 26-23 overtime thriller on the road against the Los Angeles Rams. Since that NFL odds result, the Rams, 49ers, and Seattle Seahawks have emerged as the top three teams in the NFC West. San Francisco has been forced to navigate the continued injury status of quarterbacks Mac Jones and Brock Purdy. Meanwhile, veteran Matthew Stafford has been able to stay in the Rams lineup. On Sunday afternoon, the 49ers host the revenge-seeking Rams in one of the most important games of the 2025 season.
Los Angeles Rams at San Francisco 49ers NFL Betting Information
| Date and Time: | Sunday, November 9, 2025, 4:25 p.m. ET |
|---|---|
| Location: | Levi’s Stadium, Santa Clara, CA |
| TV Coverage: | FOX |
| Los Angeles Rams | -3½ ( -115 ) | 49½ ( -110 ) | -195 |  |
| San Francisco 49ers | +3½ ( -105 ) | 49½ ( -110 ) | +170 | |
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Rams at 49ers Betting Odds Overview
First and foremost for gamblers is to check the status of San Francisco QBs Mac Jones and Brock Purdy.
Overall, the 49ers are one of the most popular teams on the board. Especially when they play at home, San Francisco is a popular team with squares. However, that can mean inflated prices for the Niners at Levi’s Stadium.
The Rams are not necessarily a popular brand, but they do carry respect. Sharps will like the revenge angle and the possibility of an enhanced road team price. Wise Guys consistently love a quality road for the value that they consistently offer.
Los Angeles Rams Team Overview
Last game, the Los Angeles Rams won 34-10 against the New Orleans Saints as 14.5-point home favorites. The game went to a push on the total of 44. As a result, Los Angeles is 6-2 straight up, 6-2 against the spread, and 3-4-1 over/under the sports betting total.
Los Angeles ranks 9th for total offense, 4th for passing, 18th for rushing, 8th for scoring, and 9th for fewest turnovers committed. In comparison, Los Angeles ranks 7th in total defense, 13th vs. the pass, 11th vs. the rush, 2nd in fewest points allowed, and 18th in takeaways.
San Francisco 49ers Team Overview
Last game, the San Francisco 49ers won 34-24 against the New York Giants as 2.5-point road favorites. The game went over the total of 47. Now, San Francisco is 6-3 straight up, 5-4 against the spread, and 5-3-1 over/under the NFL Football Betting total.
Overall, San Francisco ranks 13th for total offense, 7th for passing, 26th for rushing, 23rd for scoring, and 27th for fewest turnovers committed. San Francisco ranks 16th for total defense, 18th vs. the pass, 15th vs. the rush, 10th for fewest points allowed, and 30th for takeaways.
Mac Jones was the QB and was 19/24 for 235 yards with two TDs and no interceptions.
Rams at 49ers Betting Trends
The Rams have been one of the most profitable road teams on the board. To show, Los Angeles covered the spread in 13 of their last 18 away matchups. The Rams went under the total in five of their last eight road tilts.
On the other hand, the 49ers have not been a reliable betting value at home. San Francisco covered the spread in only four of their last ten home games. The 49ers went under the total in six of their most recent ten home tilts.
In the series between the Rams and 49ers, the Rams got the money in four of their last five meetings. Additionally, the Rams and Niners went over the total in five of their last six games.
Specifically in San Francisco, the Rams have cashed in four of their last seven visits against the 49ers, including the last two. Only two of the last ten games between the Rams and Niners at San Francisco went over the total.
Rams at 49ers SBG Free Picks
In this situation, the Rams will offer more NFL Betting value in a series and situation where they excel. As mentioned earlier, the Rams are a strong road betting value.
Rams at 49ers SBG Best Bets:
Los Angeles Rams