NFL betting in the fourth week of the preseason is usually full of backup players and unpredictable play. That may not be the case in this football betting matchup though. The wildcard in this NFL betting matchup is quarterback Peyton Manning. He has not played any of the preseason games for the Colts as he was recovering from injury but he should see action in this game and that makes the Colts an interesting NFL betting choice in NFL odds week 4 action.
NFL betting in the preseason saw the two teams meet last year in NFL odds week 4 preseason action and the game was very dull. The Bengals won a battle of backups 14-6. NFL betting history shows that the same thing happened a few years ago when the Colts played only two starters and again two years ago when they played only one.