The Houston Texans are coming off two consecutive playoff seasons. Namely, the arrivals of QB CJ Stroud and head coach DeMeco Ryans transformed the franchise. At the beginning of the partnership, not much was expected from the NFL odds. But Houston took advantage of a weak AFC South Division to make gains. However, the Jacksonville Jaguars and Indianapolis Colts have made dramatic improvements, while the Texans fell back. Houston has no margin for error if it wants a third straight playoff campaign. On Thursday night, the Texans host the always tough Buffalo Bills.
Buffalo Bills vs. Houston Texans NFL Betting Information
| Date and Time: | Thursday, November 20, 2025, 8:15 p.m. ET |
|---|---|
| Location: | NRG Stadium, Houston, TX |
| TV Coverage: | Prime Video |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Bills | -6 ( -110 ) | 43½ ( -110 ) | -275 |  |
| Texans | +6 ( -110 ) | 43½ ( -110 ) | +226 | |
| ||||
Bills at Texans Betting Odds Overview
Although the Texans are coming off two playoff campaigns, they have fallen back. Due to inconsistent offensive play, the Texans have wasted the effort of an outstanding defensive performance. Houston has been a poor betting value this year, and Stroud has had recent concussion issues.
In this matchup, Buffalo is the much more popular brand, having been a regular Super Bowl contender. The Bills have the credibility of being a team that has played for high stakes over the past several years. Of course, the Bills will get the more favorable road team price.
Buffalo Bills Team Overview
Last game, the Buffalo Bills won 44-32 against the Tampa Bay Buccaneers as 6-point home favorites. The game went over the total of 46.5. As a result, Buffalo is 7-3 straight up, 5-5 against the spread, and 5-5 over/under the sports betting total.
Buffalo ranks 4th for total offense, 8th for passing, 2nd for rushing, 5th for scoring, and 18th for fewest turnovers committed. In comparison, Buffalo ranks 12th for total defense, 2nd vs. the pass, 30th vs. the rush, 14th for fewest points allowed, and 16th for takeaways.
Late on, Buffalo has covered three out of its most recent four games. Buffalo went under the total in four of its last six matchups. Buffalo is in 2nd place in the AFC East Division.
Houston Texans Team Overview
Last game, the Houston Texans won 16-13 against the Tennessee Titans as 5.5-point road favorites. The game went under the total of 37. Now, Houston is 5-5 straight up, 4-6 against the spread, and 3-6-1 over/under the NFL Football Betting
total.
Overall, Houston ranks 20th for total offense, 16th for passing, 23rd for rushing, 22nd for scoring, and 9th for fewest turnovers committed. Houston ranks 1st for total defense, 3rd vs. the pass, 3rd vs. the rush, 1st for fewest points allowed, and 6th for takeaways.
Late on, Houston has covered two out of its most recent five games. Houston went over the total in one of its last four matchups. Houston is in 3rd place in the AFC South Division.
Bills at Texans Betting Trends
Buffalo has covered the spread in six of its last 11 away games. Additionally, the Bills went under the total in three of their most recent four road tilts.
In comparison, Houston lost only five of its last 16 home games against the spread. The Texans went over the total in only five of their most recent 20 home tilts.
In the series between the Bills and Texans, Buffalo covered the spread in three of the last five meetings. Also, the Bills and Texans went under the total in seven of their last eight games.
Specifically in Houston, the Texans covered the spread in four of their last five games against the Bills. The Bills and Texans went under the total in their last five meetings in Houston.
Bills at Texans SBG Free Picks
As mentioned earlier, the Texans have provided good NFL Betting value at home and against the Bills. This series trends strongly under the total at Houston. Finally, Buffalo’s brand popularity will keep the Houston price advantageous.
Bills at Texans SBG Best Bets: Houston Texans and Under the Total.