Last year, the San Francisco 49ers were wiped out by injuries and suffered a lost season with a record of 6-11. For 2025, the 49ers could emerge as a classic beaten favorite that comes back strong, like a quality stock coming off a brief dip. Certainly, gamblers like the 49ers in the NFL future Odds to take the NFC West title. Since Kyle Shanahan took over as head coach of the San Francisco 49ers in 2017, they have made the playoffs four times with two Super Bowl appearances and two losses in the NFC championship game.
2025 SBG NFL Futures San Francisco 49ers
| Odds to Win Super Bowl Championship: | +2000 |
|---|---|
| Odds to Win NFC: | +750 |
| Odds to Win NFC West Division: | +160 |
| Over/Under Win Total: | 10.5 |
2025 San Francisco 49ers Schedule
- Week 1: Sept. 7 at Seattle Seahawks
- Week 2: Sept. 14 at New Orleans Saints
- Week 3: Sept. 21 vs. Arizona Cardinals
- Week 4: Sept. 28 vs. Jacksonville Jaguars
- Week 5: Oct. 2 at Los Angeles Rams
- Week 6: Oct. 12 at Tampa Bay Buccaneers
- Week 7: Oct. 19 vs. Atlanta Falcons
- Week 8: Oct. 26 at Houston Texans
- Week 9: Nov. 2 at New York Giants
- Week 10: Nov. 9 vs. Rams
- Week 11: Nov. 16 at Cardinals
- Week 12: Nov. 24 vs. Carolina Panthers
- Week 13: Nov. 30 at Cleveland Browns
- Week 14: BYE
- Week 15: Dec. 14 vs. Tennessee Titans
- Week 16: Dec. 22 at Indianapolis Colts
- Week 17: Dec. 28 vs. Chicago Bears
- Week 18: Jan. 3 or 4 vs. Seahawks
Following a second Super Bowl heartbreak to the Kansas City Chiefs in February 2024, the Niners were a future market favorite to return the following season. In turn, the 2024 season was an online wagering disaster.
The 49ers desperately need their two most recent draft classes to produce and make up for the many veteran departures this offseason. But they already took a hit with the loss of second-year safety Malik Mustapha. He is expected to miss the start of the season after sustaining a knee injury in last year’s finale.
San Francisco is banking on its defensive front upgrades in the draft to help star defenders Nick Bosa and Fred Warner. Also, the arrivals of Mykel Williams, Alfred Collins, and Nick Martin could improve the team’s pass rush and run defense.
But the 49ers neglected their 2025 NFL futures needs on the offensive line. And they have a hole at guard with Aaron Banks signing with the Green Bay Packers. Brock Purdy should be OK without Deebo Samuel, who was traded to the Washington Commanders. By the 49ers, the cause was taken by Ricky Pearsall, and they re-signed Brandon Aiyuk and Jauan Jennings the prior offseason. In turn, the inexperienced players should get a boost from Trent Williams and Christian McCaffrey if they stay healthy this season.
San Francisco 49ers Team History
Born in 1946 as members of the All-American Football Conference, the San Francisco 49ers have a rich history that has earned them a spot among the NFL’s legacy franchises.
In 1981, the 49ers forged their first dynasty. Bill Walsh led them to three Super Bowl championships from 1981 through 1988. And the team he built won another one under George Seifert the year after Walsh retired. Also, Seifert won the franchise’s final Super Bowl in 1994. San Francisco missed the playoffs only once, from 1983 through 1998. Since 2012, the 49ers have made three more Super Bowls, losing each time.