At the onset, in its opening game of the season, the South Carolina Gamecocks wore down the Virginia Tech Hokies for an important win in Atlanta, GA. Last week was supposed to serve as a College Football lines breather for head coach Shane Beamer and his Cocks. South Carolina hosted the FCS South Carolina State Bulldogs to serve as a tune-up for this week’s SEC opener against the Vanderbilt Commodores. South Carolina got the win. Meanwhile, Vanderbilt scored an impressive blowout win on the road against Virginia Tech. Now, South Carolina will host Vanderbilt on Saturday.
Vanderbilt Commodores at South Carolina Gamecocks NCAAF Betting Information
| Date and Time: | Saturday, September 13, 2025, 7 p.m. ET |
|---|---|
| Location: | Williams-Brice Stadium, Columbia, SC |
| TV Coverage: | ESPN or SECN |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Vanderbilt | +5½ ( -105 ) | 47 ( -110 ) | +177 |  |
| South Carolina | -5½ ( -115 ) | 47 ( -110 ) | -205 | |
| ||||
Vanderbilt Commodores Team Overview
Last week, the Vanderbilt Commodores beat the Virginia Tech Hokies 44-20 as 1.5-point road dogs. The game went over the offshore betting total of 45.5. As a result, Vanderbilt is 2-0 straight up, 2-0 against the spread, and 1-1 over the total. Vandy has national metrics of 30th for total offense, 25th for scoring offense, 5th for total defense, and 30th for points allowed.
Diego Pavia threw for 193 yards and two touchdowns to lift the Vanderbilt Commodores to a victory over the Virginia Tech Hokies on Saturday. Pavia completed 12 of 18 and threw touchdown passes of 54 yards to Brycen Coleman and 26 yards to Tre Richardson for the Commodores, who rallied from a 10-point halftime deficit.
The Commodores used a powerful rushing attack to dominate the second half. They scored touchdowns on their first five second-half possessions, with Richardson’s terrific one-handed touchdown grab with 24 seconds left in the third quarter giving Vanderbilt its first lead. In sum, the Commodores had 262 yards rushing and put the game away in the fourth quarter with three touchdowns, including two on runs by Sedrick Alexander.
Virginia Tech was outgained 307-21 total yards in the second half. Namely, Kyron Drones threw for 134 yards and a score and rushed for a touchdown to lead the Hokies.
South Carolina Gamecocks Team Overview
Last game, the South Carolina Gamecocks won 38-10 against South Carolina State. South Carolina is 20 straight up, 1-1 against the spread, and 0-2 under the total. Overall, South Carolina ranks 120th nationally in total offense, 60th in scoring offense, 53rd in total defense, and 28th in points allowed.
Namely, Vicari Swain returned two punts for touchdowns to rescue a struggling offense for No. 10 South Carolina Gamecocks as the Gamecocks beat South Carolina State Bulldogs early Sunday. The kickoff was delayed more than two hours because of lightning in the area.
South Carolina scored more from its special teams and defense than from its offense. Also, Jaron Willis returned a fumble for a score, and LaNorris Sellers couldn’t get the offense going for a second week. South Carolina looked like it was up past its bedtime, trailing 3-0 before Swain eluded a tackler right on top of him and then ran 64 yards for a touchdown. His second TD was a 42-yard return after he picked up a partially blocked punt just before it stopped rolling. Late on, Swain said South Carolina’s special teams noticed Wofford blocked a punt and returned a kickoff for touchdowns in an opening game loss to South Carolina State last week.
Vanderbilt at South Carolina SBG Free Picks
To conclude, Vanderbilt offers excellent CFB odds value against a South Carolina team struggling on offense.
Vanderbilt at South Carolina SBG Best Bet: Vanderbilt Commodores.