In their last game, the South Florida Bulls led the Memphis Tigers 31-17 entering the 4th quarter. In turn, College Football Playoff visions were dancing in their heads. However, the Bulls imploded in a 34-31 loss. Finally, the winning TD came with 1:07 left. Following that College Football odds heartbreaker, the USF Bulls had a desperately needed bye. The question is whether USF will roar back to life or if the Memphis debacle will ruin their season. This week, South Florida gets a Thursday night home game with the UTSA Roadrunners. UTSA has fallen into difficult times.
UTSA Roadrunners vs. South Florida Bulls NCAAF Betting Information
| Date and Time: | Thursday, November 6, 2025, 7:30 p.m. ET |
|---|---|
| Location: | Raymond James Stadium, Tampa, FL |
| TV Coverage: | ESPN |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| UTSA Texas San Antonio | +14 ( -110 ) | 68 ( -110 ) | +400 |  |
| South Florida | +14 ( -110 ) | 68 ( -110 ) | +400 | |
| ||||
UTSA at South Florida Betting Odds Overview
Once upon a time, UTSA was a popular brand with sharps and bargain hunters. UTSA made the jump to the American Athletic Conference and has not reached parity at that level. UTSA’s inability to succeed in the AAC has turned off gamblers. Certainly, squares will not see UTSA as an appealing road team against South Florida.
South Florida earned credibility this season with wins over Boise State and Florida. Still, the loss at Memphis was a difficult pill for gamblers to swallow. But USF has plenty of offense to light up a terrible UTSA defense.
UTSA Team Overview
Last game, the UTSA Roadrunners won 48-26 against the Tulane Green Wave as 5.5-point home dogs. The game went over the total of 54.5. As a result, UTSA is 4-4 straight up, 4-4 against the spread, and 6-2 over/under the online wagering total.
UTSA ranks 26th for total offense, 43rd for passing, 24th for rushing, 48th for scoring, and 24th for fewest turnovers committed. In comparison, UTSA ranks 125th for total defense, 131st vs. the pass, 97th vs. the rush, 112th for fewest points allowed, and 60th for takeaways.
South Florida Bulls Team Overview
Last game, the South Florida Bulls lost 34-31 to the Memphis Tigers as 3-point road favorites. The game went over the total of 59. Now, South Florida is 6-2 straight up, 6-2 against the spread, and 5-3 over/under the College Football odds total.
Overall, South Florida ranks 9th for total offense, 36th for passing, 14th for rushing, 7th for scoring, and 101st for fewest turnovers committed. USF ranks 93rd for total defense, 128th vs. the pass, 27th vs. the rush, 71st for fewest points allowed, and 14th for takeaways.
UTSA at South Florida Betting Trends
In like manner to its straight-up problems, UTSA has been a poor value on the road. The Roadrunners covered the spread in three of their most recent 13 away games. UTSA went under the total in only two of its last five home games.
Of major concern is USF’s strong home performance. The Bulls are unbeaten against the spread in their last five home games. South Florida went under the total in two of their last five home tilts.
UTSA at South Florida SBG Free Picks
In this situation, USF has the matchup advantage of its prolific offense against the defenseless Roadrunners. UTSA will likely be too satisfied after their upset win over Tulane. South Florida had two weeks to prepare.
UTSA at South Florida SBG Best Bet: USF Bulls.