Once upon a time, the Oregon Ducks and USC Trojans were rival contenders in the Pac-12 Conference. But in the era of conference realignment and consolidation, both schools have joined the Big Ten Conference. On Saturday, Oregon’s Senior Day home finale will be a big College Football Betting showdown. The Ducks host the Trojans in a game with College Football Playoff implications. Oregon is in the thick of the CFP race. Meanwhile, USC has fought its way back in after a midseason slump. The Big Ten has undoubtedly become better thanks to USC and Oregon.
USC Trojans at Oregon Ducks NCAAF Betting Information
| Date and Time: | Saturday, November 22, 2025, 3:30 p.m. ET |
|---|---|
| Location: | Autzen Stadium, Eugene, OR |
| TV Coverage: | CBS |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| USC | +9½ (-112) | 59½ (-112) | +295 |  |
| Oregon | -9½ (-108) | 59½ (-108) | -375 | |
| ||||
USC at Oregon Betting Odds Analysis
The Trojans and Ducks are major brands with the betting public. Oregon will draw most of the casual sector support as the power home team. Simultaneously, USC is expected to garner significant support from knowledgeable individuals and bargain hunters, positioning itself as a formidable road team.
USC Trojans Team Overview
Last game, the USC Trojans rallied from a 21-7 second-quarter deficit to win 26-21 against the Iowa Hawkeyes as 6.5-point home favorites. The game went under the total of 48.5. As a result, USC is 8-2 straight up, 5-5 against the spread, and 5-5 over/under the offshore betting total.
USC ranks 7th for total offense, 10th for passing, 29th for rushing, 11th for scoring, and 69th for fewest turnovers committed. In comparison, USC ranks 47th in total defense, 41st vs. the pass, 63rd vs. the rush, 37th in fewest points allowed, and 43rd in takeaways.
Lately, USC has covered three out of its most recent five games. USC went under the total in four of its last five matchups. USC is tied for third place in the Big Ten Conference with Oregon.
Oregon Ducks Team Overview
Last game, the Oregon Ducks won 42-13 against the Minnesota Golden Gophers as 27-point home favorites. The game went over a total of 45.5. Now, Oregon is 9-1 straight up, 5-4-1 against the spread, and 5-5 over/under the College Football Betting total.
Overall, Oregon ranks 12th for total offense, 60th for passing, 9th for rushing, 7th for scoring, and 10th for fewest turnovers committed. Oregon ranks 3rd for total defense, 1st vs. the pass, 20th vs. the rush, 6th for fewest points allowed, and 53rd for takeaways.
Lately, Oregon has covered two out of its most recent five games. Oregon went under the total in two of its last three matchups.
USC at Oregon Betting Trends
Of major concern is that USC covered the spread in only three of its most recent 14 away games. The Trojans went over the total in only one of their most recent eight away games.
Oregon has been a reliable betting value at Autzen Stadium. To show, the Ducks covered the spread in six of their last nine home games. Oregon went under the total in five of its most recent eight home games.
In the series between Oregon and USC, the Ducks have gotten the money in six of their last nine games with the Trojans. The Ducks and Trojans went over the total in six of their most recent nine matchups.
Specifically in Oregon, USC came away with the cash in two of its last three visits. The Ducks and Trojans went over the total in three of their last four meetings at Oregon.
USC at Oregon SBG Free Picks
In this situation, we have a “helmet sticker” matchup of two power brands. USC offers greater value as a quality contender with a more favorable road team price. As mentioned earlier, the Trojans show excellent value at Oregon.
USC at Oregon SBG Best Bet:
USC Trojans