Indiana hosts USC on Saturday in a ranked College Football Odds Big Ten matchup that carries playoff implications for both programs. Overall, the Hoosiers enter at 8-1 overall and 5-1 in conference play. They are ranked around No. 6 nationally, after a 23-16 overtime win over Minnesota to close October.
The Indiana defense has been the foundation of the season. Overall, IU is allowing just over 12 points per game. They rank near the top of the country in yards and rushing yards allowed.
Offensively, Josh Hoover has thrown for 1,860 yards with 19 touchdowns. Turbo Richard and Lee Beebe have powered a productive ground game. Charlie Becker leads the receiving corps with 875 yards and nine scores. Indiana comes off a bye after consecutive overtime victories. Now it will look to control the tempo at Memorial Stadium.
Overall, SC arrives at 7-2 and 4-2 in the Big Ten, ranked in the teens. Following a 30-18 upset of then-No. 2 Ohio State on October 31. Jayden Maiava has been the catalyst, throwing for more than 2,500 yards with 20 touchdowns. And the Trojans rank near the top nationally in passing yards per game.
King Miller has handled most of the carries, and Trent Mosley has been a reliable deep threat. The win over Ohio State marked one of the program’s most significant victories in years. Earlier losses to Oregon and Wisconsin showed the offense can stall against physical defenses.
Both teams are coming off byes. That should leave them relatively fresh for an afternoon kickoff on CBS.
USC Trojans at Indiana Hoosiers NCAAF Betting Information
| Date and Time: | Saturday, November 14, 2026, with kickoff at 3:30 p.m. Eastern Time |
|---|---|
| Location: | Memorial Stadium in Bloomington, Indiana. |
| TV Coverage: | CBS |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| USC Trojans | +7½ ( -115 ) | 50½ ( -110 ) | +234 |  |
| Indiana Hoosiers | -7½ ( -105 ) | 50½ ( -110 ) | -286 | |
| ||||
USC visits Indiana on Saturday, November 14, 2026, with kickoff at 3:30 p.m. Eastern Time at Memorial Stadium in Bloomington. The Online Wagering matchup is on CBS as a ranked Big Ten matchup.
USC Trojans at Indiana Hoosiers Matchup Analysis
Indiana’s defensive efficiency creates the primary tension in this College Football Betting matchup. The Hoosiers allow opponents to convert third downs at just over 31 percent. Thus, ranking near the top of the country in that category. And they rank even higher in red-zone touchdown rate allowed.
Those marks have forced opposing offenses into longer fields and lower-value possessions. In turn, that aligns with their overall success rate allowed near the best in the nation.
USC converts third downs at roughly 50 percent and ranks near the top in success rate and EPA per pass. Yet the Trojans have been less consistent in finishing drives. USC is scoring on about 82 percent of red-zone trips. While ranking outside the top 90 nationally in that area.
Indiana’s ability to generate negative plays on early downs could push USC into more predictable third-down situations. Specifically, that is where the Hoosiers’ pressure package has been most effective.
USC’s pass-heavy approach on competitive downs produces higher expected points added than Indiana’s more balanced, run-leaning offense. Compared to Indiana’s more balanced, run-leaning offense. The Trojans rank among the leaders in yards per completion and completion percentage. This has allowed them to stress defenses that play softer coverage.
However, Indiana’s front has limited opponent yards per rush to one of the lowest marks in the country. And it ranks highly in sack rate. Thus, creating a potential mismatch against USC’s protection when the Trojans face pressure.
SBG Free Picks
To summarize, Sharps like USC for the side and the game to go under the total.
Indiana has covered only once in nine games this season. Indiana’s defense has held opponents under 15 points per game for most of the season.
SBG Best Bet: USC Trojans and Under the Total.