At the onset of the season, neither the Missouri Tiers nor the South Carolina Gamecocks were in the conversation as SEC championship favorites. However, South Carolina and Mizzou were certainly touted for New Year’s Day bowl possibilities and some big wins along the way. So far, Mizzou and South Carolina are on different paths. Mizzou is rolling, and USC is coming off a bad loss. Now, this week in Columbia, Missouri, the Tigers host the Gamecocks in one of the great emerging College Football lines rivalries from the SEC. Gamblers are expecting a highly competitive matchup.
South Carolina Gamecocks at Missouri Tigers
| Date and Time: | Saturday, September 20, 2025, 7 or 7:30 p.m. ET |
|---|---|
| Location: | Faurot Field, Columbia, MO |
| TV Coverage: | ABC or ESPN |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| South Carolina | +13½ ( -110 ) | 46½ ( -115 ) | +386 |  |
| Missouri | -13½ ( -110 ) | 46½ ( -105 ) | -505 | |
| ||||
South Carolina Gamecocks Team Overview
Last week, the South Carolina Gamecocks were shocked in a 31-7 Offshore betting loss to the Vanderbilt Commodores as 3-point home favorites. The game went under the total of 49. Overall, South Carolina ranks 117th for total offense, 98th for scoring offense, and 99th for fewest turnovers committed. Defensively, South Carolina ranks 46th for total defense, 46th for fewest points allowed, and 52nd for takeaways.
Diego Pavia completed 18 of 25 passes for 177 yards and two touchdowns, helping Vanderbilt post an impressive upset. Additionally, adding injury to insult, South Carolina quarterback LaNorris Sellers – a potential Heisman Trophy candidate — exited in the second quarter and did not return. Before taking a hit to the head from Langston Patterson, Sellers was 6-for-7 passing with 94 yards and an interception.
In relief of Sellers, Luke Doty completed 18 of 27 passes for 148 yards and an interception for the Gamecocks. Correlate South Carolina fell at home against Vanderbilt for the first time in 18 years.
Missouri Tigers Team Overview
Last week, the Mizzou Tigers won 52-10 against Louisiana 52-10 as 27.5-point home favorites. The game went over the total of 47. As a result, Missouri is 3-0 straight up, 3-0 against the spread, and 3-0 over the total. Mizzou has national metrics of 4th for total offense, 7th for scoring offense, 5th for total defense, and 39th for fewest points allowed.
Ahmad Hardy rushed for 250 yards and three touchdowns on 22 carries Saturday as No. 25 Missouri hammered visiting Louisiana. Hardy scored on runs of 7, 71 and 7 yards for the Tigers. Meanwhile, quarterback Beau Pribula threw for 174 yards and accounted for three touchdowns, two through the air. Backup running back Marquise Davis added 113 yards and a score on 20 carries. Overall, Missouri outgained the Ragin’ Cajuns 606121.
South Carolina at Missouri Betting Trends
Late on South Carolina has been a strong value as a road dog with eight payouts in their last ten games in that role. Five of their last seven games in that role went under the total.
Missouri has been a solid home favorite with 12 payouts in its last 18 games in that situation. The Tigers went over the total in four of their last six games at Faurot Field.
In this series between Mizzou and South Carolina, the Tigers have covered the spread in eight of the last 11 meetings, including six straight. Mizzou and South Carolina went under the total in 10 of their most recent 13 games. Specifically at Faurot Field, Mizzou got the money against South Carolina in four of their most recent five matchups. Five of the last six games at Faurot Field between the Tigers and Gamecocks went under the total.
South Carolina at Missouri SBG Free Picks
As mentioned earlier, Mizzou has the upper hand in this series with the CFB odds. Overall, the Tigers are a strong home team.
South Carolina at Missouri SBG Best Bet:
Missouri Tigers