At the onset of the season, Oregon is 2-1 and ranked around twentieth. They started with a 34-27 win over Boise State. Previously, the Ducks suffered a 39-31 College Football Odds loss at Oklahoma State, and an 84-0 flattening of Portland State.
Namely, Dante Moore has the Ducks scoring nearly 50 points a game and throwing for more than 300 yards. Evan Stewart and the rest of the skill group are making big plays when the pocket is clean. Dan Lanning’s club opens Big Ten play on the road and is looking to start a four-game winning streak against USC.
Last week, the Trojans climbed to 4-0 and ranked twelfth after a 42-35 win at Rutgers. Jayden Maiava has the offense humming, and King Miller has given Lincoln Riley a reliable run game. USC is already into conference play and will treat this as the first true home test of the season at the Coliseum.
Of great concern is that Oregon has won the last four meetings and eight of the last ten. Including the last two in Los Angeles. Both teams can score in bunches. So the game looks like an early-season statement for the West Coast side of the Big Ten. NBC will carry it in the late-afternoon window.
Oregon Ducks at USC Trojans NCAAF Betting Information
| Date and Time: | Saturday, September 26, 2026, 7:30 pm ET. |
|---|---|
| Location: | Los Angeles Memorial Coliseum, Los Angeles, California. |
| TV Coverage: | Peacock |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Oregon Ducks | -3½ ( EV ) | 63½ ( -105 ) | -164 |  |
| USC Trojans | +3½ ( -120 ) | 63½ ( -116 ) | +136 | |
| ||||
Oregon visits USC on Saturday, September 26, 2026. Kickoff is at 7:30 p.m. Eastern at the Los Angeles Memorial Coliseum. NBC has the Sports Betting matchup, with streaming on Peacock.
Oregon Ducks at USC Trojans Matchup Analysis
The College Football Betting matchup turns on whether Oregon can keep Dante Moore from the mistakes that showed up at Oklahoma State. And whether USC can make the Ducks one-dimensional. Moore has been prolific when protected, pushing the ball downfield to Evan Stewart and living in the red zone. Of course, that is where Oregon has been perfect.
Meanwhile, Lincoln Riley’s defense will try to win first down with pressure and force Moore into the kind of hurried throws that turned the Stillwater game. If the Trojans can get him off schedule, Oregon’s rushing attack will be pressured. Oregon has been merely average on the ground and would have to carry more than it wants to on the road.
By contrast, for the USC offense the question is whether Oregon’s front can slow King Miller enough to put Jayden Maiava in obvious passing downs. Miller has been the stabilizer for a Trojans offense that already has four games of work.
Of course, Maiava can beat you through the air if the run sets up play-action. Balanced against an Oregon pass defense has been middle of the pack. The Ducks need takeaways. So far, they have a plus-four turnover margin. In comparison, USC has been even. A short field or two would change the math in a game both teams can light up.
SBG Free Picks
The number is fluctuating around a field goal either way, with some books having Oregon a slight favorite and others putting USC at home on the plus side. In turn, Wise Guys will take Oregon to cover the small number.
The Ducks have won four straight in the series and the last two in Los Angeles. In turn, their offense is built to travel. USC is unbeaten but just survived against a terrible Rutgers team. USC indeed owns a 4-0 record against that slate. But that doesn’t erase Oregon’s edge when these two play.
Finally, the total is near 62.5. Both teams can score in a hurry. Neither defense has been stout enough to keep this in the fifties. Hence, sharps lean over the total.
SBG Best Bet: Oregon Ducks and Over the Total.