At the outset, Ohio State enters the Nov. 7 home College Football Odds matchup against Oregon as a clear favorite. OSU’s season has been marked by both high expectations and recent setbacks.
Overall, the Buckeyes sit at 6-2 and 4-1 in the Big Ten after dropping a 30-18 decision at USC on Oct. 31. That result is expected to drop them in the rankings after they climbed as high as No. 2.
Now OSU returns to Ohio Stadium. They continue to rely on a stout defense that has limited opponents to roughly 15 points per game. The offense adjusts without starting quarterback Julian Sayin.
Sayin has been sidelined indefinitely since suffering a throwing-shoulder injury late in the win at Indiana. Thus, true freshman Luke Fahey is taking over under center. Wide receiver Jeremiah Smith remains the primary offensive threat and a leading Heisman contender. Hence, giving Ohio State a reliable playmaker even as the quarterback situation remains fluid.
Oregon arrives in Columbus with a 5-3 record and a 3-2 conference mark. That is well off the preseason pace that had the Ducks ranked near the top of the country. Starting quarterback Dante Moore is out for the remainder of the season with a concussion. Hence, leaving Dylan Raiola to run the offense after the Ducks also parted ways with their offensive coordinator.
Oregon has shown flashes this season. Including a recent win over Northwestern. But it has dealt with inconsistency and turnovers in games without Moore.
In sum, the College Football Betting series favors Ohio State, and the Buckeyes won the most recent meeting 41-21 in the 2025 Rose Bowl.
Oregon Ducks at Ohio State Buckeyes NCAAF Betting Information
| Date and Time: | Saturday, November 7, 2026, with kickoff set for 3:30 p.m. Eastern Time |
|---|---|
| Location: | Ohio Stadium in Columbus, Ohio |
| TV Coverage: | CBS |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Oregon Ducks | +7 ( -105 ) | 47½ ( -115 ) | +230 |  |
| Ohio State Buckeyes | -7 ( -115 ) | 47½ ( -105 ) | -286 | |
| ||||
The Oregon Ducks visit the Ohio State Buckeyes on Saturday, November 7, 2026, with kickoff set for 3:30 p.m. Eastern Time at Ohio Stadium in Columbus, Ohio. The Offshore Bookmaker matchup will air nationally on CBS, with streaming available on Paramount+.
Oregon Ducks at Ohio State Buckeyes Matchup Analysis
Ohio State’s defense ranks among the nation’s best in yards allowed. In turn, it has limited opponents to roughly 15 points per game for most of the season. Ohio State faces an Oregon offense that has struggled to sustain drives and convert on third down.
The Ducks have leaned on a pass-leaning approach under Dylan Raiola. Yet they average under 4 yards per rush. They have generated only modest explosive plays against quality fronts.
Meanwhile, Ohio State’s ability to generate havoc and keep opponents behind the chains gives the Buckeyes a clear edge here. However, the Buckeye unit showed vulnerability to screens and long catch-and-runs in the loss at USC. Consider that they allowed two plays of 69 and 70 yards that flipped field position early.
On the other hand, Ohio State’s offense is operating with freshman Luke Fahey at quarterback and Jeremiah Smith as the primary target. The Buckeyes hold a pronounced advantage against an Oregon defense that allows more than 24 points and nearly 376 yards per game.
Consider that Fahey completed 21 of 38 passes for 260 yards in his first start at USC. Smith finished with 10 catches for 83 yards and a touchdown while continuing to set Big Ten receiving records. The Buckeyes rank near the top nationally in yards per pass attempt.
SBG Free Picks
In conclusion, Ohio State should cover. The Buckeyes’ defensive efficiency and home-field advantage at Ohio Stadium outweigh the uncertainty at quarterback.
SBG Best Bet: Ohio State and Under the Total.