On Saturday night, the FOX network will go from Big Noon to Big Midnight with an attractive Big Ten matchup. To illuminate, the USC Trojans will host the Michigan State Spartans on Saturday night from the LA Memorial Coliseum. Both schools have shown improvement over the past few seasons. Namely, Jonathan Smith of Michigan State and Lincoln Riley of USC are head coaches in need of a breakout season with the College Football odds. Smith is in Year 2 and is quickly getting Sparty off the mat. Meanwhile, Riley is on the hot seat but may finally deliver.
Michigan State Spartans at USC Trojans
| Date and Time: | Saturday, September 20, 2025, 11 p.m. ET |
|---|---|
| Location: | LA Memorial Coliseum, Los Angeles, CA |
| TV Coverage: | FOX |
Odds at SBG Sportsbook
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Michigan State | +18½ ( -110 ) | 56 ( -110 ) | +561 |  |
| USC | -18½ ( -110 ) | 56 ( -110 ) | -800 | |
| ||||
Michigan State Spartans Team Overview.
Last week the Michigan State Spartans won 31-24 against the FCS Youngstown State Penguins as 24-point home favorites. The game went over the Offshore betting total of 55. As a result, Michigan State is 3-0 straight up, 0-3 against the spread, and 2-1 over the total. Overall, Michigan State has national metrics of 74th for total offense, 52nd for scoring offense, and 87th for fewest turnovers committed. Michigan State ranks 71st for total defense and 76th for fewest points allowed.
Aidan Chiles passed for 270 yards and a touchdown and added 76 rushing yards as Michigan State remained unbeaten. Also, Nick Marsh caught six passes for 94 yards for the Spartans before departing with a leg injury. The severity of the injury wasn’t immediately known.
USC Trojans Team Overview
Last game, the USC Trojans won 33-17 over the Purdue Boilermakers as 20.5-point road favorites. The game went under the total of 59.5. As a result, USC is 3-0 straight up, 2-1 against the spread, and 2-1 over the total. USC ranks 2nd for total offense and 2nd for scoring offense. By contrast, USC ranks 58th for total defense, 44th for scoring defense, and 5th for takeaways.
Namely, Jayden Maiava threw for 282 yards and rushed for a touchdown while defensive tackle Jamaal Jarrett returned an interception for a score. Hence, Southern California opened Big Ten play with a win over Purdue Saturday night in West Lafayette, Ind.
In sum, Maiava completed 17 of 28 passes as the Trojans rolled up 460 total yards and kept the ball for 34:07. Ja’Kobi Lane caught three passes for 115 yards. At the same time, Waymond Jordan and Eli Sanders added 77 and 75 rushing yards, respectively. The Trojans outgained the Boilermakers 263-134 in the first half, enabling them to overcome six penalties for 70 yards.
Michigan State at USC Betting Trends
Michigan State got the money in four of its most recent six away games. Additionally, the Spartans went under the total in five of their last eight road tilts.
In sum, USC got the cash in seven of its most recent eight home games. The Trojans went over the total in six of their last seven games at the LA Coliseum.
Michigan State at USC SBG Free Picks
On this occasion, USC has more playmakers to cover the College Football odds eventually. USC has long had more talent than Michigan State, who is improving but not quite ready to compete at this level.
Michigan State at USC SBG Best Bet:
USC Trojans