One of the greatest and most ancient SEC rivalries will renew on Saturday from the Grove in Oxford, MS. The Ole Miss Rebels will host the LSU Tigers in a game that will have College Football Playoff implications. LSU has the look of a determined team that is seeking redemption after two subpar seasons. Head coach Brian Kelly has improved the roster, and it shows against the College Football odds. Ole Miss head coach Lane Kiffin has taken the Ole Miss program to new heights, making it the best it has ever been. Ole Miss is getting close to CFP caliber.
LSU Tigers at Ole Miss Rebels Betting Information
| Date and Time: | Saturday, September 27, 2025, 3:30 p.m. ET |
|---|---|
| Location: | Vaught-Hemmingway Stadium, Oxford, MS |
| TV Coverage: | ABC |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| LSU | +2½ ( -105 ) | 55½ ( -110 ) | +115 |  |
| Mississippi | -2½ ( -115 ) | 55½ ( -110 ) | -135 | |
| ||||
LSU Tigers Team Overview
Last game, the LSU Tigers routed Southeast Louisiana 56-10 as 49-point home favorites. The game went over the sportsbook total of 60. Now, LSU is 4-0 straight up, 2-2 against the spread, and 1-3 under the total.
LSU has national metrics of 72nd for total offense, 31st for passing, 112th for rushing,77th for scoring, and 73rd for fewest turnovers committed. By contrast, the Tigers rank 18th for total defense, 10th for fewest points allowed, and 9th for takeaways.
Garrett Nussmeier threw three touchdown passes and ran another score. Hence, No. 3 LSU had a breakout offensive performance in a victory against FCS Southeastern Louisiana on Saturday night in Baton Rouge, La.
In sum, Nussmeier completed 25 of 31 passes for 273 yards. Previously, the Tigers hadn’t scored more than 23 points in any of their first three games. LSU scored touchdowns on eight consecutive possessions. LSU had four rushing touchdowns after totaling two in the first three games.
Ole Miss Rebels Team Overview
Last week, the Ole Miss Rebels won 45-10 against the Tulane Green Wave as 11.5-point home favorites. The game went under the total of 61. As a result, Ole Miss is 4-0 straight up, 3-1 against the spread, and 3-1 over the total.
Ole Miss has national metrics of 9th for total offense, 12th for scoring, but 93rd for turnovers. In comparison, the Rebels rank 71st for total defense, 25th against the pass, 121st against the rush, and 44th for fewest points allowed. Ole Miss ranks 107th for takeaways.
Trinidad Chambliss threw two touchdown passes and rushed for 112 yards, and No. 13 Ole Miss dominated on defense against Tulane. Chambliss started in place of injured Austin Simmons (ankle) for a second consecutive game. In turn, he completed 17 of 27 passes for 307 yards for the Rebels.
LSU at Ole Miss Betting Trends
LSU has been in the red in its recent away games. To show, LSU covered only four of its most recent 11 away games. Seven of the last ten LSU road games went over the total.
By contrast, Ole Miss has been a solid betting value at home. Ole Miss got the cash in ten of its last 16 home games. Ole Miss went under the total in nine of its most recent 13 home games.
In this historic series, LSU is 6-2-1 against the spread vs. Ole Miss. Six of the last eight games between the Tigers and Rebels went over the total. Specifically at Ole Miss, the Rebels have had much better results. To illuminate, Ole Miss is 4-1-1 against the spread when hosting LSU. Three of the last four meetings at Ole Miss between the Tigers and Rebels went over the total.
LSU at Ole Miss SBG Free Picks
In this situation, LSU is stepping into a probable trap with the College Football odds. As was previously noted, Ole Miss does well against the Bayou Bengals at home.
LSU at Ole Miss SBG Best Bet:
Ole Miss Rebels