Following a promising 4-0 start, the Louisville Cardinals were upset at home against the rising Virginia Cavaliers. That loss in the College Football lines was shocking for a team aspiring to win the ACC championship. Since then, head coach Jeff Brohm has had two weeks to prepare The Ville for its biggest game of the season. Louisville will hit the road to take on the Miami-FL Hurricanes, who are coming off a bye week, too. Miami has national championship aspirations but can’t afford to look past the Cardinals. Louisville will arrive with focus, ability, and determination.
Louisville Cardinals at Miami-FL Hurricanes
| Date and Time: | Friday, October 17, 2025, 7 p.m. ET |
|---|---|
| Location: | Hard Rock Stadium, Miami Gardens, FL |
| TV Coverage: | ESPN or ESPN2 |
| Louisville | +13½ (-107) | 51½ (-112) | +415 |  |
| Miami, FL | -13½ (-113) | 51½ (-108) | -550 | |
| ||||
Louisville Cardinals Team Overview
Louisville is coming off a bye week. Last game, the Cardinals lost 30-27 against the Virginia Cavaliers as 6.5-point home favorites. As a result, Louisville is 4-1 straight up, 1-4 against the spread, and 3-2 over the offshore betting total.
The Louisville Cardinals have national metrics of 62nd for total offense, 21st for passing, 113th for rushing, 29th for scoring, and 82nd for fewest turnovers committed. In turn, Louisville ranks 12th in total defense, 8th against the pass, 30th against the rush, 47th in fewest points allowed, and 30th in takeaways.
Miami-FL Hurricanes Team Overview
Miami is coming off a bye week. Last game, Miami beat the Florida State Seminoles 28-22 as 4-point road favorites. The Hurricanes and Seminoles went under the total of 54.5. Now, Miami is 5-0 straight up, 4-1 against the spread, and 2-3 under the total.
The Miami Hurricanes have national metrics of 42nd for total offense, 40th for passing, 62nd for rushing, 35th for scoring offense, and 7th for fewest turnovers committed. Additionally, Miami ranks 16th in total defense, 35th against the pass, 13th against the rush, 9th in fewest points allowed, and 51st in takeaways.
Louisville at Miami-FL Betting Trends
Louisville has struggled to show value on the road. Specifically, the Cardinals have achieved only four payouts in their last 12 games. In seven of Louisville’s last nine away games, the total score exceeded the betting line.
Lately, Miami has been a strong home betting value. The Hurricanes got the cash in five of their most recent six home games. Four of Miami’s most recent seven home games went under the total.
In the series between Louisville and Miami-FL, the Hurricanes covered the spread in three of the most recent four meetings. Additionally, the Cardinals and Hurricanes have gone over the total in their last four games.
Specifically in Miami, the Cardinals got the money in two of their most recent three matchups. The Canes and Cards went over the total in three straight games at Miami.
Louisville at Miami-FL SBG Free Picks
Louisville has one of the worst rushing attacks in the nation. As a result, the Cardinals have red zone issues. Of significant concern is that Louisville has a tendency to turn the ball over.
Miami is one of the best-looking teams in the country. But Louisville has a strong defense and passing attack that may keep them within the big number. In this context, the odds for the Hurricanes are higher than they should be. Louisville has enough to stay within the number at the very least.