At the beginning of the season, there was optimism that the Kansas Jayhawks and Iowa State Cyclones would have success in College Football odds. Instead, Kansas and Iowa State have not justified that optimism. Kansas must win one of its final two games to qualify for a bowl bid. Last game, Iowa State snapped a 4-game losing streak with an upset win at TCU. As a result of their win, the Cyclones clinched bowl eligibility. However, Iowa State had a steep decline from its 12th-place ranking in the AP earlier this year.
Kansas Jayhawks vs. Iowa State Cyclones NCAAF Betting Information
| Date and Time: | Saturday, November 22, 2025, Noon, ET |
|---|---|
| Location: | Jack Trice Stadium, Ames, IA |
| TV Coverage: | FS1 |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Kansas | +4½ ( -112 ) | 55½ ( -112 ) | +154 |  |
| Iowa State | -4½ ( -108 ) | 55½ ( -108 ) | -185 | |
| ||||
Kansas at Iowa State Betting Odds Analysis
Saturday marks the Senior Day home finale for the Cyclones. Iowa State is not where gamblers expected it to be, but a bowl bid has helped ease the pain. Neither Kansas nor Iowa State is profitable this season. Iowa State has a good reputation for home games, thanks to past epic upsets. Kansas is a hard sell to gamblers as a road team with a weak defense.
Kansas Jayhawks Team Overview
Last game, the Kansas Jayhawks lost 24-20 against the Arizona Wildcats as 5.5-point road dogs. The game went under the total of 56. As a result, Kansas is 3-4 straight up, 5-5 against the spread, and 4-6 over/under the online wagering total.
Kansas ranks 69th for total offense, 72nd for passing, 65th for rushing, 55th for scoring, and 43rd for fewest turnovers committed. In comparison, Kansas ranks 74th in total defense, 52nd vs. the pass, 100th vs. the rush, 74th in fewest points allowed, and 122nd in takeaways.
Late on, Kansas has covered one out of its most recent four games. Kansas went over the total in three of its last four matchups. Kansas is in 12th place in the Big 12 Conference. Kansas trails Texas Tech by three games.
Iowa State Cyclones Team Overview
Last game, the Iowa State Cyclones won 20-17 against the TCU Horned Frogs as 7.5-point road dogs. The game went under the total of 58. Now, Kansas is 6-4 straight up, 4-5-1 against the spread, and 4-6 over/under the College Football odds total.
Overall, Iowa State ranks 66th for total offense, 71st for passing, 58th for rushing, 77th for scoring, and 98th for fewest turnovers committed. Iowa State ranks 65th for total defense, 70th vs. the pass, 78th vs. the rush, 38th for fewest points allowed, and 44th for takeaways.
Late on, Iowa State has covered one out of its most recent five games. Iowa State went under the total in three of its last four matchups. Iowa State is in 11th place in the Big 12 Conference. Iowa State trails Texas Tech by three games.
Kansas at Iowa State Betting Trends
Kansas got the money in only six of its most recent 18 away games. Additionally, the Jayhawks went under the total in just 7 of their last 20 road games.
In comparison, Iowa State failed to cover only two of its last seven home games. The Cyclones went under the total in seven of their most recent 20 home games.
In the series between Iowa State and Kansas, the Jayhawks have won and covered the last three meetings. Kansas and Iowa State went over the total in four of their last six meetings.
Specifically at Iowa State, the Cyclones covered the spread in four of their last six games with Kansas. Iowa State and Kansas went over the total in two of their last three games at Iowa State.
Kansas at Iowa State SBG Free Picks
In this situation, Iowa State has a true home-field advantage. As mentioned earlier, Kansas is a weak value on the road and at Iowa State. Iowa State should be able to run the ball effectively against the weak KU rush defense.
Kansas at Iowa State SBG Best Bet: Iowa State Cyclones.