Due to conference realignment, Missouri and Kansas last met in 2011. But that ends on Saturday afternoon in Columbia, MO. Faurot Field will host the renewal of hate, rage, and College Football lines passion. Not to mention two aspiring teams for the College Football Playoff. But while KU is firing on all cylinders, Mizzou is missing its potential starting QB. Once upon a time, the Missouri Tigers and Kansas Jayhawks had one of the most bitter and intense rivalries in college football. In fact, Mizzou and KU had the oldest college football rivalry west of the Mississippi River.
Kansas Jayhawks at Missouri Tigers NCAAF Betting Information
| Date and Time: | Saturday, September 6, 2025, 3:30 p.m. ET |
|---|---|
| Location: | Faurot Field, Columbia, MO |
| TV Coverage: | ESPN2 |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Kansas | +6½ ( -110 ) | 51 ( -108 ) | +200 |  |
| Missouri | -6½ ( -110 ) | 51 ( -112 ) | -240 | |
| ||||
Kansas Jayhawks Team Overview
In their last game, the Kansas Jayhawks won 46-7 against Wagner as 46.5-point home favorites. The game went under the online betting total of 57.5.
Kansas easily defeated FCS opponent Wagner on Friday night at remodeled David Booth Kansas Memorial Stadium. The game was not in doubt after Kansas went up 29-0 midway through the second quarter. But the Jayhawks were not immune to mistakes. They’ll need to clean up those mistakes as they renew their rivalry with Missouri next Saturday in Columbia, Mo.
The Jayhawks had a red-zone interception late in the second quarter and fumbled at the Wagner goal line in the fourth quarter. They were just 4-of-10 on third down. Also, they gave up a long touchdown on a fourth-down conversion by Wagner.
Wagner quarterback Jack Stevens was 13-of-20 for 90 yards and a touchdown. Leading 29-7 at halftime, Kansas resumed its dominance on its first possession of the second half, going 75 yards in two plays. And then Jalon Daniels found Emmanuel Henderson Jr. on a 62-yard bomb for the score. That ended Daniels’ night with 280 passing yards on 18-of-25 passes. In sum, he also threw four touchdowns, including two to Henderson, plus the interception.
Missouri Tigers Team Overview
Last game, the Missouri Tigers won 61-6 against Central Arkansas as 38.5-point home favorites. The game went over the total of 52.5. Namely, Beau Pribula accounted for 348 total yards and four touchdowns in each team’s season opener in Columbia, Mo.
Previously a Penn State transfer, Pribula completed 23 of 28 passes for 283 yards and two touchdowns while rushing 10 times for 65 yards and two scores. Pribula entered the season in a battle for the starting job with holdover backup Sam Horn.
Tigers coach Eli Drinkwitz planned to play Pribula in the first half and Horn in the second half. And then he would make a decision on a permanent starter for the Sept. 6 visit from Kansas. However, Horn never got his chance in the second half because he came in to run one play in the first quarter and was promptly knocked out with a leg injury. Following halftime, Horn was seen on the sideline with a leg cast and crutches.
Pribula started with the biggest possible bang, throwing his first pass of the year 49 yards to Marquis Johnson for a touchdown just 3:54 into the game.
Kansas at Missouri SBG Free Picks
To conclude, Kansas has two strong games under its belt and the CFB odds QB advantage. Kansas gets the additional advantage of the road team discount.
Kansas at Missouri SBG Best Bet: Kansas Jayhawks.