So far in his tenure as head coach of the USC Trojans, Lincoln Riley has not met College Football Betting expectations. At the beginning, there were dreams of national titles and a new dynasty. Instead, Riley has been above average and nowhere near a national championship contender. Last week, USC hosted a tough but outclassed Northwestern Wildcats team. The Men of Troy delivered a payout to stay in the College Football Playoff race. Now comes another tough opponent with better players than Northwestern. The Iowa Hawkeyes suffered a heartbreaker at the gun.
Iowa Hawkeyes vs. USC Trojans NCAAF Betting Information
| Date and Time: | Saturday, November 15, 2025, 3:30 p.m. ET |
|---|---|
| Location: | LA Memorial Coliseum, Los Angeles, CA |
| TV Coverage: | BTN |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Iowa | +7 ( -112 ) | 49½ ( -112 ) | +200 |  |
| USC | -7 ( -108 ) | 49½ ( -108 ) | -245 | |
| ||||
Iowa at USC Betting Odds Analysis
Iowa is a favorite of Wise Guys and bargain hunters. The Hawkeyes are in the black this year and play the type of football that keeps them in games against anyone. Of course, the USC brand easily attracts the casual sector. Especially when playing at home, the Trojans are a popular, though expensive, draw.
Iowa Hawkeyes Team Overview
Last game, the Iowa Hawkeyes lost 27-24 against the Oregon Ducks as 4.5-point home dog. The game went under the total of 41.5. As a result, Iowa is 6-3 straight up, 6-2-1 against the spread, and 4-4 over/under the offshore bookmaker total.
Iowa ranks 123rd for total offense, 133rd for passing, 48th for rushing, 61st for scoring, and 25th for fewest turnovers committed. In comparison, Iowa ranks 4th in total defense, 5th vs. the pass, 17th vs. the rush, 5th in fewest points allowed, and 30th in takeaways.
USC Trojans Team Overview
Last game, the USC Trojans won 38-17 against the Northwestern Wildcats as 14.5-point home favorites. The game went over the total of 54. Now, USC is 5-4 straight up, 5-4 against the spread, and 5-4 over/under the College Football Betting
total.
Overall, USC ranks 2nd for total offense, 10th for passing, 23rd for rushing, 7th for scoring, and 84th for fewest turnovers committed. USC ranks 47th for total defense, 48th vs. the pass, 58th vs. the rush, 44th for fewest points allowed, and 42nd for takeaways.
Iowa at USC Betting Trends
Iowa has been an impressive value on the road. To illustrate, the Hawkeyes lost only four of their last 17 games against the spread on the road. Iowa went under the total in nine of its last 12 away games.
In like manner, USC has been profitable at the LA Coliseum. The Trojans got the cash in eight of their most recent ten games. The Trojans went over the total in 15 of their last 20 home games.
Since 2022, the Hawkeyes and Trojans have met once. Iowa won and covered against USC in the 2019 Holiday Bowl. The game went over the total.
Iowa at USC SBG Free Picks
In this situation, Iowa offers more value as the quality road team. The Hawkeyes have the better defense and special teams and don’t beat themselves. Thus, they should stay within the number.
Iowa at USC SBG Best Bet: Iowa Hawkeyes.