Two years ago, the Illinois Fighting Illini and Indiana Hoosiers were considered losers with the College Football odds. To show, gamblers wanted nothing to do with them. In fact, Indiana and Illinois were “go against” teams on the college football board. However, those days are over. Head coaches Bret Bielema of Illinois and Curt Cignetti of Indiana have engineered remarkable turnarounds. Now, Illinois and Indiana are in the fight for the Big Ten championship. On Saturday, the Hoosiers will host the Fighting Illini in one of the top matchups of the weekend.
Illinois Fighting Illini at Indiana Hoosiers
| Date and Time: | Saturday, September 20, 2025, 7:30 p.m. ET |
|---|---|
| Location: | Memorial Stadium, Bloomington, IN |
| TV Coverage: | NBC |
Odds at SBG Sportsbook
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Illinois | +4½ ( +105 ) | 52½ ( EV ) | +183 |  |
| Indiana | -4½ ( -125 ) | 52½ ( -120 ) | -215 | |
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Indiana Hoosiers Team Overview
Last week, the Indiana Hoosiers won 73-0 against Indiana State as 47.5-point home favorites. The game went over the Online betting total of 61.5. As a result, Indiana is 3-0 straight up, 2-1 against the spread, and 2-1 over the total. Indiana has national metrics of 1st for total offense, 26th for scoring offense, 63rd for total defense, and 20th for fewest points allowed.
Fernando Mendoza and Omar Cooper Jr. celebrated records, and No. 22 Indiana was nearly perfect as it pummeled Indiana State. In posting the program’s largest shutout in 124 years, the Hoosiers finished with the third-most points and yards (680) in a game in their history. Also, the Hoosiers accumulated 301 yards on the ground, the third straight game with 300 or more.
In turn, Mendoza played only in the first half and set a record for the highest completion percentage by a Hoosier quarterback. The Cal transfer completed 19 of 20 passes for 270 yards and five touchdowns. His 95 percent mark broke Peyton Ramsey’s 92.9 percent rate set against Eastern Illinois on Sept. 7, 2019.
Illinois Fighting Illini Team Overview
Last game, the Illinois Fighting Illini beat the Western Michigan Broncos 38-0 as 27.5-point home favorites. The game went under the total of 51. The Fighting Illini are 3-0 straight up, 3-0 against the spread, and 3-0 over the total. Illinois has national metrics of 65th for total offense, 14th for scoring offense, and 1st for fewest turnovers committed. In comparison, Illinois ranks 26th for total defense, 5th for fewest points allowed, and 97th for takeaways.
Luke Altmyer threw for two touchdowns and rushed for a score. At the same time, Kaden Feagin added 100 rushing yards and a score. Altmyer completed 17 of 26 passes for 196 yards for the Fighting Illini.
Illinois at Indiana Betting Trends
Overall, Illinois is one of the best values on the board in away games. The Fighting Illini got the money in 16 of its last 20 away games. Five of their last eight games in that role went over the College Football odds total.
Specifically at home, the Hoosiers have covered seven of their most recent nine games. Six of Indiana’s last nine home games went over the total.
In the series between Illinois and Indiana, the Hoosiers covered the last five meetings with four straight up wins. Specifically at home, Indiana got the cash in five of its last seven against the Fighting Illini.
Illinois at Indiana SBG Free Picks
In this situation, Illinois will offer more value in an even matchup. The Fighting Illini will get the more favorable price as the away team.