At the beginning of the season, the Clemson Tigers were touted as national championship material. But those College Football Betting future market expectations blew up within the first month of action. Head coach Dabo Swinney bears the burden for a letdown season from hell. Clemson has still not fully adapted to the transfer portal or the NIL culture of today’s college football. Now, Clemson is fighting for a minor bowl bid. This week brings a dangerous opponent. The Tigers will host the Duke Blue Devils, who have the more impressive body of work in 2025.
Duke Blue Devils vs. Clemson Tigers NCAAF Betting Information
| Date and Time: | Saturday, November 1, 2025, Noon ET |
|---|---|
| Location: | Memorial Stadium, Clemson, SC |
| TV Coverage: | ACCN |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Duke Blue Devils | +3 ( +105 ) | 55½ ( -110 ) | +145 |  |
| Clemson Tigers | -3 ( -125 ) | 55½ ( -110 ) | -165 | |
| ||||
Duke at Clemson Betting Odds Analysis
The Duke Blue Devils still have the reputation for being a basketball school. This branding actually helps Duke’s betting value. The casual sector avoids Duke, helping ensure gamblers don’t overpay on the Blue Devils.
On the other hand, the Clemson Tigers are a power megabrand. Despite not being a serious national championship contender, Clemson carries an inflated price based on its past reputation. Squares are still drawn to Clemson at Death Valley. Sharps will look hard at those extra points going to Duke.
Duke Blue Devils Team Overview
Last game, the Duke Blue Devils lost 27-18 against the Georgia Tech Yellow Jackets as 3.5-point home dogs. The game went under the total of 60.5. As a result, Duke is 4-3 straight up, 3-4 against the spread, and 5-2 over/under the online wagering total.
Duke ranks 23rd for total offense, 6th for passing, 84th for rushing, 42nd for scoring, and 57th for fewest turnovers committed. In comparison, Duke ranks 76th for total defense, 104th vs. the pass, 47th vs. the rush, 79th for fewest points allowed, and 23rd for takeaways.
Clemson Tigers Team Overview
Last game, the Clemson Tigers lost 35-24 against the SMU Mustangs as 3.5-point home favorites. The game went over the total of 50.5. Now, Clemson is 3-4 straight up, 2-5 against the spread, and 3-4 over/under the College Football Betting total.
Overall, Clemson ranks 65th for total offense, 24th for passing, 115th for rushing, 84th for scoring, and 116th for fewest turnovers committed. Clemson ranks 38th for total defense, 73rd vs. the pass, 23rd vs. the rush, 41st for fewest points allowed, and 54th for takeaways.
Duke at Clemson Betting Trends
Late on, Duke is 6-2-1 against the spread in away games. Additionally, Duke went over the total in 12 of its most recent 17 away games.
On the other hand, Clemson has been a weak home value. The Tigers got the cash in only 12 of their most recent 19 home games. Clemson went over the total in 12 of their last 20 games at Death Valley.
In the series between Duke and Clemson, the Tigers covered four of the last six meetings. However, Duke covered the most recent two games. Three of the last four games in this series went under the total.
Specifically at Clemson, the Tigers have cashed in five of their most recent six games against Duke. Three of the last four games in this series at Clemson went under the total.
Duke at Clemson SBG Free Picks
As mentioned earlier, Clemson has been a poor value this year. However, the Tigers have the better defense and dominate their series with Duke. Clemson will receive a home-team discount due to its poor season. Despite all that, Clemson has the better players.
Duke at Clemson SBG Best Bet: Clemson Tigers.