Bet on March Madness in the first round and consider the #7 vs. #10 matchup. Unlike the myth of betting the #12 vs. the #5 where the #5 has actually done better over the past five years than the #12, this 7-10 matchup is a moneymaker if you take the #7 seeds in March Madness gambling. Let’s take a look at the numbers for this matchup.