March Madness betting lines begin with the first round, continue with the second, third, fourth round, semifinals and conclude with the Final. Let’s take a look at some of the specific numbers when it comes to each of the rounds in March Madness gaming lines. March Madness betting lines show that #1 seeds have never lost in the opening round. That makes sense since they are playing very weak #16 seeds in the first round of March Madness odds. The #2 Seeds have almost been as good losing only a few times in March Madness betting lines in tournament history. Things begin to change in March Madness betting lines in the first round as #3 seeds have lost about 17% of the time. #4 seeds have lost about 20% of the time. Things continue to show that the seeds start to get upset a little bit as the #5 seed has lost almost a third of the time in the first round. The #6 seed has actually done a little bit better than the #5 seed historically in the first round of March Madness betting lines. The #7 seed has done about as expected winning about 60 % of the time.