The Louisville Cardinals travel to Littlejohn Coliseum to face the Clemson Tigers on Saturday. Correlate that this is a key late-season ACC matchup with both teams in the middle-to-upper tier of the conference standings. Louisville sits around 6th-7th, while Clemson is positioned around 5th. A College Basketball odds win could help either squad solidify a higher seed in the ACC Tournament (top-4 gets a double-bye) and boost their NCAA Tournament resume with a Quad 1 opportunity.
Louisville Cardinals, under head coach Pat Kelsey in Year 2, have been strong offensively (averaging around 86.8 PPG) with efficient shooting. They’re good in ACC play, showing improvement from last season. However, road games remain a test. Still, the recent February form has been solid. Louisville has a consistent rebounding edge and assist numbers that highlight its balanced attack. Coming off recent games like vs. North Carolina, this is a tough back-to-back road stretch.
The Clemson Tigers have a slight edge in conference record and a strong home performance. They’ve been competitive in the ACC, with recent results including a loss to Florida State. But they’ve also posted solid metrics overall. Defense and home-court energy at Littlejohn (known for tough atmosphere) are strengths. They’re fighting to hold position ahead of teams like Louisville, Miami, and NC State.
Louisville Cardinals at Clemson Tigers NCAAB Betting Information
| Date and Time: | Saturday, February 28, 2026, 2 p.m. ET |
|---|---|
| Location: | Littlejohn Coliseum, Clemson, SC |
| TV Coverage: | ESPN2 |
| Betting Online Odds at SBG: | Click Here |
Louisville at Clemson Betting Odds Analysis
Historically, this series has been competitive, with Louisville winning some recent tournament matchups. Specifically, the matchup pits Louisville’s high-powered offense against Clemson’s home strength and conference positioning.
Expect a physical, mid-major-style battle—both teams play at a decent pace but can grind defensively in big spots. Overall, Clemson has a slight home edge in a close, important ACC clash that could go down to the wire. Louisville’s offense might have upset potential if it controlled the tempo.
Louisville Cardinals Team Overview
The Louisville Cardinals are 20-7 straight up, 13-14 against the spread, and 11-16 over/under the offshore betting total. Late on, Louisville has covered two out of its last four games. At the same time, the Cardinals have gone over the total in three of their previous five matchups.
Louisville has national rankings of 21st in scoring offense, 58th in field goal percentage, 66th in 3-point field goal percentage, 16th in free throw percentage, and 20th in offensive rebounding. In comparison, the Cardinals rank 93rd for scoring defense, 45th for field goal percentage permitted, 104th for 3-point field goal percentage allowed, and 120th for defensive rebounding.
Clemson Tigers Team Overview
The Clemson Tigers are 20-8 straight up, 16-12 against the spread, and 11-17 over/under the college basketball total. Late on, Clemson has covered two out of their last six games. At the same time, the Tigers have gone under the total in four of their previous six matchups.
Clemson has national rankings of 254th in scoring offense, 146th in field goal percentage, 194th in 3-point field goal percentage, 177th in free throw percentage, and 229th in offensive rebounding. In comparison, the Tigers rank 13th for scoring defense, 46th for field goal percentage permitted, 63rd for 3-point field goal percentage allowed, and 48th for defensive rebounding.
Louisville at Clemson Betting Trends
Louisville covered six consecutive games against Clemson. The Tigers and Cardinals went over the total in three of their last five games. Specifically at Clemson, Louisville covered the spread in its last two visits. Three of the last five games between the Tigers and Cardinals at Clemson went over the total.
Louisville at Clemson SBG Free Picks
Louisville enters with momentum (strong February form, efficient shooting). In comparison, Clemson has hit a rough patch with recent losses. Including defeats to teams like Virginia Tech and Duke have dropped their standing, making this a “must-protect-home” spot.
This has the potential to upset a tight ACC race. To illuminate, Louisville’s blueprint (efficient shooting, balance) matches up well if they handle the road environment. To conclude, the Cards could cover or steal it.
Louisville at Clemson SBG Best Bet: Louisville Cardinals.