Following a promising non-conference period, the Notre Dame Fighting Irish have faced significant challenges in league play. To show, they recently suffered a heartbreaking 100–97 loss to Virginia on January 27 and an 86–72 loss to Syracuse on January 31. Namely, freshman Cole Certa and Braeden Shrewsberry have been central to the offensive efforts. Notably, Certa recently delivered a standout performance, scoring the most points by an Irish player against an AP-ranked opponent since 2008.
In their second season under head coach Pat Kelsey, the Louisville Cardinals have shown significant College Basketball odds improvement. The improvement is highlighted by a 96–88 victory over No. 9 Kentucky earlier this season. Also, Louisville recorded an 88–74 comeback win against SMU on January 31.
Concurrently, Louisville is in the middle of the competitive ACC, tied for 7th in the conference standings. The team has been particularly strong at home at the KFC Yum! Center, posting an 11–2 home record. Leading the team in scoring is Ryan Conwell (19.5 points per game), who has recorded 19 double-digit scoring games this season.
Notre Dame Fighting Irish at Louisville Cardinals
| Date and Time: | Wednesday, February 4, 2026, 7 p.m. ET |
|---|---|
| Location: | KFC Yum! Center, Louisville, KY |
| TV Coverage: | ESPN2 |
| Betting Online Odds at SBG: | Click Here |
Notre Dame at Louisville Betting Odds Analysis
Notre Dame continues to play without star guard Markus Burton, who has been out since early December with a broken ankle. By contrast, Louisville recently saw the return of Khani Rooths from illness, but continues to monitor several questionable rotational players.
Notre Dame Fighting Irish Team Overview
The Notre Dame Fighting Irish are 11-11 straight up, 11-11 against the spread, and 14-8 over/under the sports betting total. Late on, Notre Dame has covered one out of their last seven games. The Irish have gone over the total in seven of their previous eight matchups.
Notre Dame has national metrics of 289th in scoring offense, 196th in field goal percentage, 115th in 3-point field goal percentage, 254th in free throw percentage, and 149th in offensive rebounding. In comparison, the Irish have national metrics of 110th for scoring defense, 152nd for field goal percentage permitted, 91st for 3-point field goal percentage allowed, and 34th for defensive rebounding.
Louisville Cardinals Team Overview
The Cardinals are 15-6 straight up, 11-10 against the spread, and 8-13 over/under the college basketball odds total. Late on, Louisville has covered two out of its last four games. The Cardinals have gone under the total in seven of their previous eight matchups.
Overall, Louisville ranks 41st nationally in scoring offense, 120th in field goal percentage, 135th in 3-point field goal percentage, 39th in free throw percentage, and 24th in offensive rebounding. The Cardinals have national metrics of 74th in scoring defense, 32nd in field goal percentage allowed, 175th in 3-point field goal percentage allowed, and 148th in defensive rebounding.
Notre Dame at Louisville Betting Trends
Louisville covered six of its last ten games against Notre Dame. Only one of the last nine games between Notre Dame and Louisville went over the total. Notre Dame failed to cover its last three games as a road dog. Louisville covered the spread in ten of its last 15 home games.
Notre Dame at Louisville SBG Free Picks
The absence of Markus Burton has been the defining story of Notre Dame’s season. Before his injury in December, Burton was the team’s primary offensive engine. At the same time, the Cardinals received a boost with the return of Khani Rooths on January 31, where he recorded a double-double (12 pts, 10 reb) in just 20 minutes.
To conclude, Louisville has significant advantages in offensive firepower, rebounding, bench depth, and turnover margin.
Notre Dame at Louisville SBG Best Bet: Louisville Cardinals.