Late on, the Houston Astros have held a tenuous lead in the American League West. The Seattle Mariners and Texas Rangers have been lurking close behind with the baseball betting odds. On Sunday night, the Astros will host the Mariners in one of the biggest games of the 2025 season. Houston has not been in top form at the most important time of the year. At the same time, Seattle has taken gamblers on a roller coaster ride. Of course, Houston is the far bigger brand at the betting window. Most important of all, they are profitable.
Seattle Mariners at Houston Astros MLB Betting Information
| Date and Time: | Sunday, September 21, 2025, 7:10 p.m. ET |
|---|---|
| Location: | Daikin Park, Houston, TX |
| TV Coverage: | ESPN |
| Betting Online Odds at SBG: | Click Here |
Mariners at Astros SBG Betting Odds Analysis
The Seattle Mariners have not been profitable this season. Specifically, on the road, they have been in deep offshore betting red ink. The Mariners have given gamblers a blood bath on the run line in 2025. Seattle is trending over the total this year.
To illuminate, the Seattle Mariners are +95 units on the moneyline and -1962 units on the run line. Seattle is -568 units on the road and is trending over the total.
At the same time, the Houston Astros have been profitable. Houston has been a reliable betting value at home. By contrast, the Astros have been in the red with the run line. Houston is trending slightly under the total this year.
To show, the Astros are +702 units on the moneyline and -419 on the run line. The Astros are +418 units at home and trending under the total.
Seattle Mariners SBG Team Overview
The Seattle Mariners are 82-68 and 82-62-6 over the total. The Mariners are battling the Houston Astros for the National League West lead. The team that is in second place will be in a prime American League wild-card position.
Late on, the Mariners are on fire with nine payouts in their last ten games. Seattle went over the total in six of their last nine tilts.
The Mariners have MLB metrics of 10th for run production, 12th for OPS, 3rd for home runs, and 4th for stolen bases. By contrast, Seattle ranks 14th for earned run average, 8th for WHIP, 7th for quality starts, 6th for fewest errors committed, and 7th for bullpen ERA.
Houston Astros SBG Team Overview
The Houston Astros are 82-69 and 69-76-6 under the total. Late on the Astros won four of their most recent six games. Houston has gone under the total in five of its most recent eight games.
Overall, Houston ranks 25th for run production, 13th for OPS, and 17th for home runs. The Astros rank 9th for earned run average, 5th for WHIP, 3rd for quality starts, and 8th for fewest errors committed. Houston ranks 10th for bullpen ERA.
Mariners at Astros Betting Trends
Overall, in the series between Houston and Seattle, the Astros have won nine of the most recent 17 meetings. Only six of the last 20 games between Seattle and Houston went over the total.
Specifically at Houston, the Astros got the cash in four of their most recent six games against the Mariners. Only six of the last 18 games between the Mariners and Astros at Houston went over the total.
Mariners at Astros SBG Free Pick
As mentioned earlier, Houston has been a more reliable MLB odds value than Seattle. And this series has trended under the total.
Mariners at Astros SBG Best Bet: Houston Astros.