No. 5 Ohio State travels to Bloomington as the slight College Football Odds favorite against the No. 7 Indiana Hoosiers. Both teams are sitting among the nation’s best at 5-1 and 6-0, respectively. The Buckeyes have rebounded from an early road loss at Texas with four straight wins. Including a 45-16 Saturday home victory over Maryland. Overall, Ohio State averaged roughly 43 points while allowing about 13.
Quarterback Julian Sayin has been efficient through the air. To show, with more than 1,700 passing yards, 17 touchdowns, and only two interceptions. Thus, giving Ohio State a high-powered attack that has also produced solid rushing production.
Indiana enters as the defending national champion and undefeated at 6-0. They won their last two games by margins of 32 and 3 points. Following a Saturday comeback road victory at Nebraska.
In sum, the Hoosiers average around 40 points and hold opponents to roughly 12 per game. Specifically, their physical defense limits explosive plays. Their offense has been balanced, relying on a ground game that complements the passing attack led by Josh Hoover.
Overall, the all-time series is dominated by Ohio State at 81-13-5. But the Hoosiers snapped a long Buckeyes streak with a 13-10 victory in last season’s Big Ten Championship Game.
That result gives this regular-season rematch at Memorial Stadium extra weight. Certainly, Indiana looks to defend its home turf and prove last year’s success was no fluke. Ohio State seeks revenge and a statement win in the Big Ten race.
Ohio State Buckeyes at Indiana Hoosiers NCAAF Betting Information
| Date and Time: | Saturday, October 17, 2026, 12:00 PM ET. |
|---|---|
| Location: | Memorial Stadium in Bloomington, Indiana. |
| TV Coverage: | FOX |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Ohio State Buckeyes | -3½ ( -114 ) | 51 ( -112 ) | -182 |  |
| Indiana Hoosiers | +3½ ( -106 ) | 51 ( -108 ) | +150 | |
| ||||
The Ohio State Buckeyes visit the Indiana Hoosiers on Saturday, October 17, 2026, with kickoff set for noon Eastern Time at Memorial Stadium in Bloomington, Indiana. The Online betting matchup is scheduled for national broadcast in the United States on FOX.
Ohio State Buckeyes at Indiana Hoosiers Matchup Analysis
Overall, Ohio State’s offense generates elite College Football Betting efficiency through the air. The Buckeyes are ranking near the top of the FBS in yards per pass attempt. Also, they are posting one of the highest EPA-per-play marks nationally.
Hence, that has allowed the Buckeyes to convert early downs into explosive gains even when the run game is more complementary than dominant. The passing success rate and explosiveness create problems for defenses that must account for downfield threats. Ohio State Buckeyes have shown they can sustain drives and capitalize on intermediate and deep looks when the protection holds.
By contrast, Indiana counters with a more run-oriented approach that averages strong yards per carry. And it ranks among the better units in rushing EPA. Its defense has been particularly effective at limiting opponent success rates and yards per rush attempt.
Specifically, the Hoosiers force teams into longer situations by controlling the line of scrimmage. Indiana has held opponents to low explosive-play rates in several contests. However, their pass defense metrics are more average and could be tested by an offense that operates at Ohio State’s level of efficiency.
SBG Free Picks
To conclude, Sharps like Ohio State as the side. The Buckeyes’ superior pass-game efficiency. And EPA metrics give them a clearer path to generating enough chunk plays and early-down success to cover the modest number. Especially against an Indiana defense that has been strong against the run but more average through the air.
Finally, Wise Guys like the under as the total play. Both teams also rank among the nation’s better units at limiting opponent success rates and explosive plays. Additionally, the physical matchup at the line of scrimmage likely keeps the combined scoring in a controlled range
SBG Best Bet: Ohio State Buckeyes and Under the Total.