The 49ers have a difficult start to the season in NFL betting and they also have a difficult closing stretch.
NFL betting online odds list San Francisco as a 2.5 point road favorite against the Seattle Seahawks in Week 1 of the regular season. Winning at Seattle has never been easy for the 49ers and the Seahawks are expected to be improved this season under new head coach Pete Carroll. It doesn’t get any easier in Week 2 for San Francisco as they host the defending Super Bowl Champion New Orleans Saints on Monday Night Football. The 49ers better not have a letdown after that game since they go to Kansas City in Week 3. The Chiefs are expected to be much better this season and winning at Arrowhead Stadium will not be easy. The 49ers stay on the road in Week 4 for a very tough game in Atlanta. They come home in Week 5 for another difficult game against Philadelphia. Their first game that looks relatively easy doesn’t come until Week 6 as they host the Oakland Raiders.
The 49ers have to go to Carolina in Week 7 and the Panthers are not an easy mark, especially at home. San Francisco then hosts Denver in Week 8 NFL betting. The bye does come at a good time for San Francisco in Week 9. The schedule does get easier for San Francisco for a few weeks after the bye. They host St. Louis in Week 10 and then host the Bucs in Week 11. They travel to Arizona for a Monday night game in Week 12. That game begins a tough stretch for the 49ers. They go to Green Bay in Week 13 and then host Seattle in Week 14. They have a very difficult game in San Diego in Week 15 and it comes on short week as they play on Thursday. They get extra rest before Week 16 at St. Louis and then they host Arizona in Week 17.
The NFC West is considered the weakest division in the NFL and the 49ers are favored over Arizona and Seattle but the schedule for San Francisco is not easy. Everyone is handing them the division title this season but it may be too soon to proclaim the 49ers champs.