The 49ers lead the overall series 7-4 and they have won two of the last three NFL betting meetings.
Football betting favors the 49ers by 4 points and the total of 41. This is a great matchup of top running backs as San Francisco has Frank Gore while Tennessee has Chris Johnson. It is Johnson who leads the NFL in rushing with 824 yards.
Tennessee is 2-5 against the football betting pointspread this season. They are 1-3 against the spread on the road. Three of the last four Tennessee road games have gone over in football betting. San Francisco is 5-1-1 against the spread this NFL betting season including 2-1 at home. The 49ers have been a lot more potent on offense now that Vernon Davis is catching the ball. He has become the favorite target of San Francisco quarterback Alex Smith who took over the starting job in place of Shaun Hill.
Tennessee has won their last five games against NFC teams. They will look to get another solid game out of Vince Young who played well last week in his first start of the season. The Titans have a lot of NFL betting talent and most people couldn’t understand why they were winless before last week. The Titans have normally been good in the month of November. They are 4-1 in their last 5 games in that month. Tennessee has been a good underdog in football betting. The Titans are 15-7 ATS in their last 22 games as an underdog. The concern for those taking the Titans in NFL betting is that Tennessee is 1-5 versus the football betting odds in their last 6 road games.
San Francisco is also good in the month of November. The 49ers are 5-1 in football betting in their last 6 games in November. San Francisco has been solid at home laying points. The 49ers are 3-1-1 in their last 5 football betting games as a home favorite.
Football betting with the total has seven of the last Tennessee games in the month of November going under. 11 of the last 15 San Francisco games at home when they were favored have gone over the football betting total. It is colder in November though and 9 of the last 13 San Francisco games have gone under the football betting total.