What looked like an easy win for the Bills a few weeks ago does not look nearly as simple now. The Bills have been in a freefall in online football betting while the 49ers look much improved under head coach Mike Singletary. Making an NFL bet on this game should be interesting.
Online football betting history shows that the Bills and 49ers rarely meet. Since 1980 they have played only eight times and only twice this decade according to online football betting stats. The Bills won the last meeting in San Francisco in 2004 by a score of 41-7 according to online football betting numbers. They also met in San Francisco in 2001 and the 49ers won 35-0 according to online football betting results. You have to go back to 1998 for the last meeting in Buffalo and it was the Bills that won 26-21.
Buffalo has been a pretty good home favorite in recent seasons, going 10-6 according to online football betting stats. The 49ers have been below .500 as a road underdog, losing almost 60% of the time in that role since 2005 according to online football betting statistics.
The Bills are a slight over team at home in recent years as the over is 16-13 since 2005 according to online football betting numbers. The 49ers have gone over the online football betting total about 60% of the time in road games during that same time period.
The Bills looked like a sure playoff team earlier in the season and gamblers were looking to make an NFL bet on the Bills each week. That is no longer the case as Buffalo will have to make a serious run late in the season to challenge for a playoff spot. Even this game against San Francisco does not look like the automatic win it was earlier in the season and is not a sure NFL bet for gamblers.
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