NFL Odds: Giants vs. 49ers

Late on Sunday afternoon, last year's Super Bowl champion New York Giants take on the NFL title runner-up San Francisco 49ers. The game in Candlestick Park in San Fran, CA, is scheduled to kick off at 4:25 PM ET, and will be televised on the FOX network.

The Giants come into this game off an easy victory at home over the winless Cleveland Browns, 41-27. In that one, New York held a 502-375 edge in offensive yards, including a 243-84 edge in rushing. They forced 3 Cleveland turnovers, including 2 interceptions, and held onto the ball for 11 more minutes than the Browns. QB Eli Manning threw 25-of-37, for 259 yards, and 3 touchdowns, while RB Ahmad Bradshaw ran for 200 yards and a touchdown on 30 carries. The Giants have scored more than 40 points twice so far this season. Start your NFL Football Betting on Giants vs. 49ers Game.

The 49ers continued their strong season in Week 5 by destroying the Buffalo Bills, 45-3. The Bills defense was nowhere to be found, as the Niners tallied 621 yards of offense, setting a franchise record. That included 310 yards passing, and 311 yards rushing from San Fran, while the Bills managed just 204 total yards. In fact, San Francisco is now the only NFL team in history to rack up at least 300 passing yards and 300 rushing yards in a single game. The 49ers also held onto the ball for 13 more minutes than Buffalo.

QB Alex Smith threw 18-of-24, for 303 yards, and 3 touchdowns. The Niners are +192 points spreadwise in their last 24 games. The Giants are 10-2-2 and 5-0-1 ATS as the visitor lately. They are 2-3 ATS on the season, and 1-1 ATS as the away underdog. The 49ers are 15-6-1 ATS recently. They are 4-1 ATS this year so far, and 2-0 ATS as a home favorite. Check the NFL Odds for Giants vs. 49ers Game.

These two teams have met seven times since 2001, with the Giants leading the series 4-3. In last year's Super Bowl, the Giants won 20-17 in overtime, after the 49ers were favored by 2 ½ points. In a November 2011 matchup, San Francisco won 27-20, after they were favored by 3 ½ points. New York has covered the spread in 5 of the last 6 meetings between these two teams.

For Sunday's game, the 49ers are 6 ½ point home favorites from SBG Global Sportsbook site. The line opened at -5 ½ for San Fran. The over/under is set at 45 ½ points.

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