They used to play twice each year as members of the NFC West but now that New Orleans is in the NFC South they do not play every year. NFL betting odds on this game have the Saints as prohibitive favorites.
NFL betting history shows that New Orleans has won 7 of the last 10 meetings between the two teams. The Saints are an even better 8-2 against the football betting pointspread in those matchups. The Saints are 5-1 straight up and 4-2 against the NFL betting pointspread in the last six games at New Orleans. Six of the last 10 games between the two teams have gone over the football betting total including three of the last four. San Francisco has also been an excellent over team on the road the past three years, going over the total more than 60% of the time according to football betting stats.
Points could come fast and furious in this NFL odds Week 4 matchup as the Saints have a powerful offense led by quarterback Drew Brees and running back Reggie Bush according to NFL betting stats. The 49ers are also vastly improved on offense this season according to NFL betting information with quarterback J.T. O’Sullivan leading the way. They also have one of the best running backs in football in Frank Gore who can impact NFL betting odds at any moment. The defensive edge probably goes to New Orleans according to NFL betting experts, but the Saints defense has never been good enough to throw a scare into any team, which is why New Orleans oftentimes fails to cover the football betting pointspread. The Saints have also been a terrible football betting home favorite in recent years, winning under 30% of the time against the NFL betting pointspread.
Take a look at the NFL odds Week 4 NFL betting numbers for this matchup and you might want to take a serious look at wagering on the NFL betting total in this game.
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