The Cardinals can clinch the NFC West with a victory. Arizona proved last week against Minnesota that they are a serious contender in football odds to reach the Super Bowl again this season.
NFL betting lines have Arizona as a 3.5 point favorite with a total of 44.5. Arizona has won four of their last five including last week 30-17 against Minnesota. Quarterback Kurt Warner threw for 285 yards and three touchdowns. His two top receivers had good games as Larry Fitzgerald caught eight passes for 143 yards and a TD while Anquan Boldin had seven catches for 98 yards and two touchdowns. "It's a middle-of-the-season game and it doesn't have a lot of bearing in the big picture, but it gives you confidence moving forward to think that we can play with anybody," Warner said. "We can play with the big dogs. The key for us is to show up like that every week."
San Francisco’s offense has come alive of late with Alex Smith at quarterback but the 49ers are still not winning enough games vs. NFL betting lines. Smith was 27 of 45 throws for a career-best 310 yards with two touchdowns last week but the 49ers lost in NFL betting lines 20-17 to Seattle. It was the sixth loss in eight games for the 49ers. "In every situation, we just found a way to screw it up," coach Mike Singletary said. "Teams that talk about going to the playoffs can't do that."
Arizona has been a good team on the road in NFL betting lines. The Cardinals are 6-1 vs. football odds in their last 7 road games. The Cardinals are also very good against division teams in NFL betting lines as they are 8-3 ATS in their last 11 vs. the NFC West. The Cardinals are 4-0 vs. NFL betting lines in their last 4 meetings at San Francisco.
San Francisco has been a very good team getting points in NFL betting lines. The 49ers are 6-0-2 vs. football odds in their last 8 games as an underdog. They are also solid on Monday night as they are 15-5 vs. NFL betting lines in their last 20 Monday games. San Francisco is 6-2-1 ATS in their last 9 home NFL betting lines games. Four of the last five Arizona road games have gone under the NFL betting lines. The last five San Francisco divisional games have gone under in football odds.