Detroit Lions at San Francisco NFL Betting

NFL betting heavily favors the San Francisco 49ers on Sunday as they host the Detroit Lions.

The Lions are not likely to have rookie quarterback Matthew Stafford for this pro football betting contest so it will be either Daunte Culpepper or Drew Stanton getting the start. Here is a look at the information and trends for this matchup between the Lions and 49ers.

NFL betting has San Francisco as a 12-point favorite against Detroit with a total of 41. For those that are considering taking the Lions plus the big NFL betting points, they definitely don’t want to see Culpepper as the starter. He has never won a start in his career for Detroit. Stanton at least gives Detroit a little hope in pro football betting. Last week Culpepper was horrible again and Stanton came in for him at the half. It is hard to take Detroit at anytime in NFL betting but with Culpepper as quarterback it simply has been a losing proposition.

San Francisco won’t be making the playoffs but they are still a big NFL betting favorite against the Lions. San Francisco is just 6-8 this season but they have been a pro football betting pointspread success going 8-4-2. They have been very solid at home going 5-2 in NFL betting. The problem for San Francisco has been inconsistent play at quarterback but Alex Smith should not have too much trouble against a poor Detroit defense.

NFL betting trends have Detroit going 2-6-1 ATS in their last 9 games overall. They have not played well on the road, going 1-5-1 ATS in their last 7 road games. The Lions are 1-3-1 ATS in their last 5 meetings in San Francisco.

San Francisco is 7-2-1 vs. the NFL betting odds in their last 10 home games. In fact, overall the 49ers are 11-5-3 ATS in their last 19 games.

Detroit has been going over the NFL betting total on the road. 23 of their last 32 road games have gone over the pro football betting number. That is different than San Francisco who has gone under in their last four home games. Seven of San Francisco’s last eight games in December have gone under the NFL betting total. In this series between the Lions and 49ers in San Francisco, the last five games have all gone under the NFL betting total.