USC at Notre Dame College Football Betting Lines

College football betting lines on Saturday include a matchup at South Bend between two Top 25 teams as #25 Notre Dame hosts #4 USC.

It is one of the best rivalries in college football and always attracts a lot of attention in college football odds.

College football betting lines have USC as a 10-point favorite against Notre Dame.  The Trojans come into the game at 4-1 after a bye last week and are in position to challenge for the national title if they can remain with only one loss. The Irish are also 4-1 this season but most people don’t believe they have played anyone.  Notre Dame leads the all time college football betting lines series 42-33-5, but USC has won the last seven meetings.

USC is averaging 28.8 points per game led by freshman quarterback Matt Barkley.  College football betting lines have him completing almost 60 percent of his passes, for 958 yards and three touchdowns.  The only loss in college football betting lines action for USC was when Barkley was injured. The running game hasn’t been great especially without the injured Stafon Johnson but Joe McKnight can still impact college football odds.  On defense the Trojans can impact college football betting lines as they are in the Top 10 in the country.

The USC defense should be tested by a Notre Dame offense led by quarterback Jimmy Clausen. He has completed 67.6 percent of his passes for 1,544 yards with 12 TDs as college football betting lines stats show. The running game is solid too with running back Armando Allen.  The problem for Notre Dame is a defense that is allowing more than 400 yards per game.

College football betting lines do favor the Trojans.  They are 21-6 vs. the college football odds at the sports book in their last 27 non-conference games.   The one concern for those wagering on college football betting lines with USC is that the Trojans are 1-5 ATS in their last 6 games as a road favorite at the sports book.

Notre Dame has not been great in college football betting lines as a home underdog. The Fighting Irish are 4-9 in college football odds in their last 13 games as a home underdog. The Fighting Irish are 0-4 vs. college football betting lines at the sportsbook in their last 4 non-conference games. The only positive is that the home team in this series is 4-1 at the sportsbook in the last 5 meetings.