Houston, we have a problem: the Louisville Cardinals

Louisville Cardinals against the Houston Cougars Betting OddsCollege football betting odds favor the Louisville Cardinals against the Houston Cougars on Thursday, November 17th at TDECU Stadium. These are the college football betting lines for that game:
 
Louisville -14 (-110) - -550 
Houston U +14 (-110) - +425

The Cards (9-1) defeated the Wake Forest Demon Deacons 44-12 on Saturday. QB Lamar Jackson threw 14 of 26 for 145 yards with one TD pass to Cole Hikutini, and ran for 153 yards on 22 carries. Traveon Samuel had 42 yards on two receptions. Brandon Radcliff ran for 141 yards and three TDs on 11 carries. Devonte Fields and Chucky Williams had nine tackles each. Fields also had three sacks. Ronald Walker returned one interception 31 yards for a TD. Blanton Creque kicked 1 of 2 field goals. The Cards have won five games in a row.  
 
The Cougars (8-2) beat the Tulane Green Wave 30-18 on Saturday. QB Greg Ward Jr. went 18 of 30 for 189 yards with two TDs passes to Chance Allen and Steven Dunbar, and ran for minus three yards and another TD on five carries. Linell Bonner had 97 yards on nine receptions. Duke Catalon ran for 50 yards on 20 carries. Tyus Bowser had 11 tackles and three sacks. The Cougars have won two games in a row. 
 
Louisville is averaging 583.2 total yards (313.2 passing and 270.0 rushing) and allowing 285.2 total yards (182.5 passing and 102.7 rushing) per game. Jackson is 184 of 314 (58.6%) for 2898 yards with 27 TDs and six picks and has run for 1336 yards and 19 TDs on 185 carries. Hikutini has 526 yards and six TDs on 38 catches. Williams has 75 combined tackles. James Hearns has eight sacks. Jaire Alexander has intercepted five passes. Regarding college football betting odds and the like; the Cards are 8-4 against the spread in their last 12 games, 2-4 against the spread in their last six games, 5-0 straight-up in their last five games, 4-2 against the spread and 5-1 straight-up in their last six road games, 2-4 against the spread in their last six games versus the Cougars, and 6-2 straight-up in their last eight games versus the Cougars.
 
Houston is averaging 452.4 total yards (283.8 passing and 168.6 rushing) and allowing 303.3 total yards (210.5 passing and 92.8 rushing) per game. Ward Jr. (probable) is 222 of 324 (68.5%) for 2608 yards with 16 TDs and eight picks and has run for 429 yards and nine TDs on 144 carries. Chance Allen has 637 yards on 44 catches and Dunbar has five receiving TDs. Matthew Adams has 55 combined tackles. Bowser has 6 ½ sacks. Howard Wilson has intercepted five passes. Concerning college football betting odds and related things, the Cougars are 0-5 against the spread in their last five games, 22-3 straight-up in their last 25 games, 1-4 against the spread and 5-0 straight-up in their last five home games, 4-2 against the spread in their last six games versus the Cards, and 2-6 straight-up in their last eight games versus the Cards.